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The effects of phys...
The effects of physical activity and estrogen treatment on rat fast and slow skeletal muscles following ovariectomy.
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- Kadi, Fawzi (författare)
- Department of Physical Education and Health, Örebro University, Örebro, Sweden
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- Karlsson, Camilla, 1977 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi,Institute of Physiology and Pharmacology,Institute of Physiology and Pharmacology, Department of Physiology, Göteborg University, Göteborg, Sweden
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- Larsson, Britt (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Department of Occupational and Environmental Medicine, Lund University Hospital, Lund, Sweden
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- Eriksson, Jennie (författare)
- Högskolan i Halmstad,Sektionen för ekonomi och teknik (SET)
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- Larval, Maria (författare)
- Högskolan i Halmstad,Sektionen för ekonomi och teknik (SET)
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- Billig, Håkan, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi,Institute of Physiology and Pharmacology,Institute of Physiology and Pharmacology, Department of Physiology, Göteborg University, Göteborg, Sweden
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- Jonsdottir, Ingibjörg H, 1966 (författare)
- Högskolan i Halmstad,Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi,Institute of Physiology and Pharmacology,Sektionen för ekonomi och teknik (SET),Institute of Physiology and Pharmacology, Department of Physiology, Göteborg University, Göteborg, Sweden
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(creator_code:org_t)
- Dordrecht : Springer, 2002
- 2002
- Engelska.
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Ingår i: Journal of muscle research and cell motility. - Dordrecht : Springer. - 0142-4319 .- 1573-2657. ; 23:4, s. 335-9
- Relaterad länk:
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Decreased estrogen production is associated with changes in the skeletal, cardiovascular and muscular systems. At the level of skeletal muscles, it has been shown that a reduction in force production occurs at menopause but the underlying mechanisms are still unknown. The aim of the study was to investigate the effects of ovariectomy on myosin heavy chain (MyHC) composition. Additionally, we studied the effects of physical activity and the combined effects of physical activity and estrogen treatment on MyHC content in ovariectomised (OX) animals. Twenty-five rats were randomly assigned to five different groups: controls, runners, OX, ovariectomised runners and ovariectomised runners receiving estrogen. Exercise consisted of voluntary running for 5 weeks. Two muscles were analysed: m. extensor digitorum longus, EDL, (fast muscle) and m. soleus (slow muscle). MyHC content was analysed on 8% gel electrophoresis. The level of running activity is reduced in OX animals and estrogen administration is associated with the normalisation of the level of physical activity. Ovariectomy induces a shift from fast to slow MyHC isoforms in both the soleus and EDL. When OX animals are allowed to run, alterations in MyHC isoforms are still observed in the EDL but not in the soleus. When physical activity is combined with estrogen treatment no alterations are observed in both muscles. In conclusion, this study shows that ovariectomy induces alterations in the contractile properties of skeletal muscles and that physical activity in combination with estrogen treatment are associated with the maintenance of slow and fast muscle characteristics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Animals
- Estrogens
- deficiency
- pharmacology
- Female
- Muscle Contraction
- drug effects
- physiology
- Muscle Fibers
- Fast-Twitch
- cytology
- drug effects
- metabolism
- Muscle Fibers
- Slow-Twitch
- cytology
- drug effects
- metabolism
- Muscle Weakness
- etiology
- metabolism
- physiopathology
- Muscle
- Skeletal
- cytology
- drug effects
- metabolism
- Myosin Heavy Chains
- drug effects
- metabolism
- Ovariectomy
- Physical Conditioning
- Animal
- Postmenopause
- metabolism
- Protein Isoforms
- drug effects
- metabolism
- Rats
- Muscle Contraction
- Physiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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