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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004722naa a2200649 4500
001oai:gup.ub.gu.se/62949
003SwePub
008240528s2003 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/629492 URI
0247 a https://doi.org/10.1053/jcan.2003.432 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lindholm, Lenau Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute4 aut
2451 0a Regional oxygenation and systemic inflammatory response during cardiopulmonary bypass: influence of temperature and blood flow variations.
264 1b Elsevier BV,c 2003
520 a OBJECTIVE: To evaluate the role of target temperature (28 degrees or 34 degrees C) in cardiac surgery on regional oxygenation during hypothermia and rewarming and systemic inflammatory response. DESIGN: Prospective, controlled, and randomized clinical study. SETTING: University hospital. PARTICIPANTS: Elderly patients (mean age 70 +/- 2 years) with acquired heart disease with an anticipated bypass time exceeding 120 minutes (n = 30). INTERVENTIONS: The patients were cooled to either 28 degrees C (n = 15) or 34 degrees C (n = 15). At hypothermia, bypass blood flow was reduced twice from full flow (2.4 L/min/m(2) body surface area [BSA]) to 2.0 L/min/m(2). MEASUREMENTS AND MAIN RESULTS: Hepatic and jugular venous oxygen tension and saturation were higher at 28 degrees C than at 34 degrees C. In comparison with the preoperative values, at 28 degrees C hepatic venous values were higher; whereas at 34 degrees C, they were lower. The reduction of pump blood flow during hypothermia, from 2.4 to 2.0 L/min/m(2)was accompanied by reductions of central, jugular, and hepatic oxygenation at both target temperatures. During rewarming, central and regional venous oxygenation decreased irrespective of the preceding temperature. The decrease was most pronounced in hepatic venous blood, with the lowest individual values <10%. Serum concentrations of C3a and IL-6 increased during hypothermia and increased further during rewarming irrespective of the preceding temperature. CONCLUSION: During cardiopulmonary bypass, hypothermia at 28 degrees C increases regional and central venous oxygenation better than at 34 degrees C. In contrast, venous oxygenation decreases during rewarming irrespective of the preceding temperature. No significant difference in the systemic inflammatory response associated with target temperature was detected.
653 a Aged
653 a Cardiopulmonary Bypass
653 a Complement C3a
653 a metabolism
653 a Coronary Circulation
653 a physiology
653 a Female
653 a Heart Diseases
653 a surgery
653 a Hemodynamics
653 a physiology
653 a Hemoglobins
653 a metabolism
653 a Humans
653 a Hypothermia
653 a Induced
653 a adverse effects
653 a Inflammation
653 a immunology
653 a Interleukin-6
653 a blood
653 a Male
653 a Oxygen
653 a blood
653 a Prospective Studies
653 a Regional Blood Flow
653 a physiology
653 a Rewarming
653 a adverse effects
7001 a Bengtsson, Anders,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care4 aut0 (Swepub:gu)xbeand
7001 a Hansdottir, Vigdis,d 1952u Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care4 aut
7001 a Lundqvist, Magnus4 aut
7001 a Rosengren, Lars,d 1954u Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap, Sektionen för laborativ neurovetenskap,Institute of Clinical Neurosciences, Section of Experimental Neuroscience4 aut0 (Swepub:gu)xrosel
7001 a Jeppsson, Anders,d 1960u Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute4 aut0 (Swepub:gu)xjepan
7102 a Göteborgs universitetb Hjärt-kärlinstitutionen4 org
7730 t Journal of cardiothoracic and vascular anesthesiad : Elsevier BVg 17:2, s. 182-7q 17:2<182-7x 1053-0770
8564 8u https://gup.ub.gu.se/publication/62949
8564 8u https://doi.org/10.1053/jcan.2003.43

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