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Rapid decrease of f...
Rapid decrease of free vancomycin in dense staphylococcal cultures.
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- Ekdahl, Christer (författare)
- Linköpings universitet,Infektionsmedicin,Hälsouniversitetet
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- Hanberger, Håkan (författare)
- Linköpings universitet,Infektionsmedicin,Hälsouniversitetet
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- Hällgren, Anita (författare)
- Linköpings universitet,Infektionsmedicin,Hälsouniversitetet
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- Nilsson, Maria (författare)
- Linköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet
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- Svensson, E (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk bakteriologi,Institute of Laboratory Medicine, Dept of Clinical Bacteriology,Division of Clinical Bacteriology, Department of Laboratory Medicine, Sahlgrenska University Hospital, Sweden
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- Nilsson, Lennart E. (författare)
- Linköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet
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(creator_code:org_t)
- 2005-09-27
- 2005
- Engelska.
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Ingår i: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. - : Springer Science and Business Media LLC. - 0934-9723 .- 1435-4373. ; 24:9, s. 596-602
- Relaterad länk:
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http://urn.kb.se/res...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Bacterial numbers in broth cultures were determined by bioluminescence assay of intracellular bacterial ATP. Broth MICs for strains of Staphylococcus epidermidis (ATCC 14990 and 35984) and Staphylococcus aureus (ATCC 25923, 29213 and 6538) were determined for cultures with different inocula (10(5)-10(8) bacteria/ml) after 24 h of incubation in supplemented Mueller-Hinton broth containing vancomycin. All of the tested strains except one were susceptible to methicillin, and all of the strains were susceptible to vancomycin. Free vancomycin concentrations in the broth cultures of all strains were determined with an agar well bioassay after 24 h of incubation. Free vancomycin concentrations and bacterial numbers of ATCC 35984 and ATCC 29213 were also determined after 0.5, 2, 4, and 8 h. In a low inoculum (10(5) bacteria/ml), the broth MICs were 1-4 microg/ml. In a high inoculum (approximately 10(8) bacteria/ml), the broth MICs increased two- to fourfold to 4-8 microg/ml. In dense inocula ( approximately 10(9)-10(10) bacteria/ml), the concentrations of free vancomycin in the broth were reduced, in most cases below the detection limit of the bioassay (
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Adenosine Triphosphate -metabolism
- Anti-Bacterial Agents -metabolism
- pharmacology
- Colony Count
- Microbial
- Humans
- Luminescence
- Staphylococcal Infections
- drug therapy
- Staphylococcus aureus
- drug effects
- metabolism
- Staphylococcus epidermidis
- drug effects
- metabolism
- Vancomycin
- metabolism
- pharmacology
- Vancomycin Resistance
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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