Autism associated with conditions characterized by developmental errors in early embryogenesis: a mini review.

• Autism is a complex developmental disorder without an established single etiology but with significant contributions from genetic studies, functional research, and neuropsychiatric and neuroradiologic investigations. The purpose of this paper is to review the findings in five studies involving individuals manifesting the characteristic findings of autism spectrum disorder associated with malformations and dysfunctions known to result from early embryogenic defects. These investigations include two associated with teratogens (thalidomide embryopathy, Mobius sequence with misoprostol) and three (most Mobius sequence cases, CHARGE association, Goldenhar syndrome) with no known etiology. These studies suggest that early embryonic development errors often involving cranial nerve palsies, internal and external ear malformations, ophthalmologic anomalies, and a variety of systemic malformations may be associated with autism spectrum disorders statistically more frequently than expected in a normal population. Although the exact time of developmental insult for each condition cannot be identified, the evidence is that it may occur as early as week 4 to 6+ of embryogenesis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Abnormalities

Multiple

Physiopathology

Adult

Autistic Disorder

Diagnosis

Epidemiology

Etiology

Child

Child

Preschool

Congenital Abnormalities

Epidemiology

Physiopathology

Craniofacial Abnormalities

Physiopathology

Developmental Disabilities

Physiopathology

Embryonic Development

Female

Goldenhar Syndrome

Diagnosis

Epidemiology

Physiopathology

Humans

Infant

Male

Middle Aged

Mobius Syndrome

Diagnosis

Epidemiology

Physiopathology

Sweden

Epidemiology

Thalidomide

Poisoning

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)