Sökning: onr:"swepub:oai:gup.ub.gu.se/66312" > IA-2 autoantibodies...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 07543naa a2201333 4500 | |
001 | oai:gup.ub.gu.se/66312 | |
003 | SwePub | |
008 | 240910s2007 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-14463 | |
009 | oai:DiVA.org:liu-108702 | |
009 | oai:lup.lub.lu.se:bad435fe-dffe-4447-b4e0-e358ddc329e7 | |
009 | oai:prod.swepub.kib.ki.se:115877410 | |
024 | 7 | a https://gup.ub.gu.se/publication/663122 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-144632 URI |
024 | 7 | a https://doi.org/10.1038/sj.gene.63644132 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1087022 URI |
024 | 7 | a https://lup.lub.lu.se/record/11409022 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1158774102 URI |
040 | a (SwePub)gud (SwePub)uud (SwePub)liud (SwePub)lud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Shin, J. H.u Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada4 aut |
245 | 1 0 | a IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5 |
264 | 1 | b Springer Science and Business Media LLC,c 2007 |
520 | a In a large case-control study of Swedish incident type I diabetes patients and controls, 0-34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients. Initial scans of allelic association were followed by more detailed logistic regression modeling that adjusted for known type I diabetes risk factors and potential confounding variables. The single nucleotide polymorphism (SNP) rs6598, located in a polyadenylation signal of GIMAP5, was associated with the presence of significant levels of IA-2 autoantibodies in the type I diabetes patients. Patients with the minor allele A of rs6598 had an increased prevalence of IA-2 autoantibody levels compared to patients without the minor allele (OR=2.2; Bonferroni-corrected P=0.003), after adjusting for age at clinical onset (P=8.0 x 10(-13)) and the numbers of HLA-DQ A1*0501-B1*0201 haplotypes (P=2.4 x 10(-5)) and DQ A1*0301-B1*0302 haplotypes (P=0.002). GIMAP5 polymorphism was not associated with type I diabetes or with GAD65 or insulin autoantibodies, ICA, or age at clinical onset in patients. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same SNP in another autoimmune disease. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a Adolescent | |
653 | a Adult | |
653 | a Autoantibodies/blood/*immunology | |
653 | a Case-Control Studies | |
653 | a Child | |
653 | a Child | |
653 | a Preschool | |
653 | a Diabetes Mellitus | |
653 | a Type 1/*genetics/*immunology/metabolism | |
653 | a Female | |
653 | a GTP-Binding Proteins/*genetics/metabolism | |
653 | a Humans | |
653 | a Infant | |
653 | a Infant | |
653 | a Newborn | |
653 | a Male | |
653 | a Polymorphism | |
653 | a Single Nucleotide | |
653 | a Sweden | |
653 | a Adolescent | |
653 | a MEDICINE | |
653 | a polyadenylation signal | |
653 | a IA-2 autoantibodies | |
653 | a GIMAP5 | |
653 | a type I diabetes | |
700 | 1 | a Janer, M.u Institute for Systems Biology, Seattle, WA, USA4 aut |
700 | 1 | a McNeney, B.u Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada4 aut |
700 | 1 | a Blay, S.u Karolinska Institutet4 aut |
700 | 1 | a Deutsch, K.u Institute for Systems Biology, Seattle, WA, USA4 aut |
700 | 1 | a Sanjeevi, C. B.4 aut |
700 | 1 | a Kockum, I.u Karolinska Institutet4 aut |
700 | 1 | a Lernmark, Åkeu Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups4 aut0 (Swepub:lu)endo-ale |
700 | 1 | a Graham, J.u Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canada4 aut |
700 | 1 | a Arnqvist, H.u Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut |
700 | 1 | a Björck, E.4 aut |
700 | 1 | a Eriksson, J.4 aut |
700 | 1 | a Nystrom, L.4 aut |
700 | 1 | a Ohlson, L. O.4 aut |
700 | 1 | a Schersten, B.4 aut |
700 | 1 | a Östman, J.4 aut |
700 | 1 | a Aili, M.4 aut |
700 | 1 | a Baath, L. E.4 aut |
700 | 1 | a Carlsson, E.4 aut |
700 | 1 | a Edenwall, H.4 aut |
700 | 1 | a Forsander, Gun,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences4 aut0 (Swepub:gu)xfgunj |
700 | 1 | a Granström, B. W.4 aut |
700 | 1 | a Gustavsson, I.4 aut |
700 | 1 | a Hanas, R.4 aut |
700 | 1 | a Hellenberg, L.4 aut |
700 | 1 | a Hellgren, H.4 aut |
700 | 1 | a Holmberg, E.4 aut |
700 | 1 | a Hornell, H.4 aut |
700 | 1 | a Ivarsson, S. A.4 aut |
700 | 1 | a Johansson, C.4 aut |
700 | 1 | a Jonsell, G.4 aut |
700 | 1 | a Kockum, K.4 aut |
700 | 1 | a Lindblad, B.4 aut |
700 | 1 | a Lindh, A.4 aut |
700 | 1 | a Ludvigsson, Johnnyu Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping4 aut0 (Swepub:liu)johlu29 |
700 | 1 | a Myrdal, U.4 aut |
700 | 1 | a Neiderud, J.4 aut |
700 | 1 | a Segnestam, K.4 aut |
700 | 1 | a Sjöblad, S.4 aut |
700 | 1 | a Skogsberg, L.4 aut |
700 | 1 | a Stromberg, L.4 aut |
700 | 1 | a Stahle, U.4 aut |
700 | 1 | a Thalme, B.4 aut |
700 | 1 | a Tullus, K.4 aut |
700 | 1 | a Tuvemo, Tu Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson4 aut0 (Swepub:uu)torstuve |
700 | 1 | a Wallensteen, M.4 aut |
700 | 1 | a Westphal, O.4 aut |
700 | 1 | a Aman, J.u Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnendokrinologisk forskning/Gustafsson4 aut |
700 | 1 | a Diabetes Incidence in Sweden Study Group, The4 aut |
700 | 1 | a Swedish Childhood Diabetes Study Group, The4 aut |
710 | 2 | a Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, British Columbia, Canadab Institute for Systems Biology, Seattle, WA, USA4 org |
773 | 0 | t Genes Immund : Springer Science and Business Media LLCg 8:6, s. 503-12q 8:6<503-12x 1466-4879x 1476-5470 |
856 | 4 | u http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17641683&dopt=Citation |
856 | 4 | u https://www.nature.com/articles/6364413.pdf |
856 | 4 | u http://dx.doi.org/10.1038/sj.gene.6364413y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/66312 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-14463 |
856 | 4 8 | u https://doi.org/10.1038/sj.gene.6364413 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-108702 |
856 | 4 8 | u https://lup.lub.lu.se/record/1140902 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:115877410 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy