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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04538naa a2200625 4500 | |
| 001 | oai:gup.ub.gu.se/66761 | |
| 003 | SwePub | |
| 008 | 240528s2007 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/667612 URI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kenchaiah, S.4 aut |
| 245 | 1 0 | a Body mass index and prognosis in patients with chronic heart failure: insights from the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program |
| 264 | 1 | c 2007 |
| 520 | a BACKGROUND: In individuals without known cardiovascular disease, elevated body mass index (BMI) (weight/height2) is associated with an increased risk of death. However, in patients with certain specific chronic diseases, including heart failure, low BMI has been associated with increased mortality. METHODS AND RESULTS: We examined the influence of BMI on prognosis using Cox proportional hazards models in 7599 patients (mean age, 65 years; 35% women) with symptomatic heart failure (New York Heart Association class II to IV) and a broad spectrum of left ventricular ejection fractions (mean, 39%) in the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) program. During a median follow-up of 37.7 months, 1831 patients died. After adjustment for potential confounders, compared with patients with BMI between 30 and 34.9, patients in lower BMI categories had a graded increase in the risk of death. The hazard ratios (95% confidence intervals) were 1.22 (1.06 to 1.41), 1.46 (1.24 to 1.71), and 1.69 (1.43 to 2.01) among those with BMI of 25 to 29.9, 22.5 to 24.9, and < 22.5, respectively. The increase in risk of death among patients with BMI > or = 35 was not statistically significant (hazard ratio, 1.17; 95% confidence interval, 0.95 to 1.43). The association between BMI and mortality was not altered by age, smoking status, or left ventricular ejection fraction (P for interaction >0.20). However, lower BMI was associated with a greater risk of all-cause death in patients without edema but not in patients with edema (P for interaction <0.0001). Lower BMI was associated with a greater risk of cardiovascular death and noncardiovascular death. Baseline BMI did not influence the risk of hospitalization for worsening heart failure or due to all causes. CONCLUSIONS: In patients with symptomatic heart failure and either reduced or preserved left ventricular systolic function, underweight or low BMI was associated with increased mortality, primarily in patients without evidence of fluid overload (edema). | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
| 653 | a Aged | |
| 653 | a Aged | |
| 653 | a 80 and over | |
| 653 | a Benzimidazoles/*therapeutic use | |
| 653 | a *Body Mass Index | |
| 653 | a Cohort Studies | |
| 653 | a Double-Blind Method | |
| 653 | a Female | |
| 653 | a Follow-Up Studies | |
| 653 | a Heart Failure/*diagnosis/drug therapy/*mortality | |
| 653 | a Humans | |
| 653 | a Internationality | |
| 653 | a Male | |
| 653 | a Middle Aged | |
| 653 | a Morbidity | |
| 653 | a Prognosis | |
| 653 | a Survival Rate/trends | |
| 653 | a Tetrazoles/*therapeutic use | |
| 700 | 1 | a Pocock, S. J.4 aut |
| 700 | 1 | a Wang, D.4 aut |
| 700 | 1 | a Finn, P. V.4 aut |
| 700 | 1 | a Zornoff, L. A.4 aut |
| 700 | 1 | a Skali, H.4 aut |
| 700 | 1 | a Pfeffer, M. A.4 aut |
| 700 | 1 | a Yusuf, S.4 aut |
| 700 | 1 | a Swedberg, Karl,d 1944u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine4 aut0 (Swepub:gu)xsweka |
| 700 | 1 | a Michelson, E. L.4 aut |
| 700 | 1 | a Granger, C. B.4 aut |
| 700 | 1 | a McMurray, J. J.4 aut |
| 700 | 1 | a Solomon, S. D.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin4 org |
| 773 | 0 | t Circulationg 116:6, s. 627-36q 116:6<627-36x 1524-4539 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/66761 |
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