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Hepatitis C impairs...
Hepatitis C impairs survival following liver transplantation irrespective of concomitant hepatocellular carcinoma.
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Melum, Espen (författare)
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- Friman, Styrbjörn, 1948 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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Bjøro, Kristian (författare)
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Rasmussen, Allan (författare)
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Isoniemi, Helena (författare)
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- Gjertsen, Henrik (författare)
- Karolinska Institutet
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- Bäckman, Lars, 1959 (författare)
- Uppsala universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Transplantationskirurgi
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Oksanen, Antti (författare)
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- Olausson, Michael, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences
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- Duraj, Frans (författare)
- Uppsala universitet,Gastrointestinalkirurgi
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- Ericzon, Bo-Göran (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2007
- 2007
- Engelska.
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Ingår i: Journal of hepatology. - : Elsevier BV. - 0168-8278 .- 1600-0641. ; 47:6, s. 777-83
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND/AIMS: Liver transplantation (LTX) is the only curative treatment for end-stage liver disease caused by hepatitis C (HCV). Hepatocellular carcinoma (HCC) is common in patients with HCV cirrhosis. METHODS: Two hundred and eighty-two HCV patients listed for LTX in the Nordic countries in a 17-year period were included. For comparison a group of patients with non-viral chronic liver disease (n=1552) was used. RESULTS: Two hundred and fifty-three (90%) patients received a first liver allograft. HCC was found in 38% of the explanted livers. Survival at 1, 3 and 5years was 82%, 69% and 61% vs. 85%, 80% and 76% for the comparison group (p<0.0001), this survival difference was also evident when excluding patients with HCC (p=0.007). HCV patients with HCC had 1, 3 and 5year survival of 73%, 52% and 46% compared with 88%, 80% and 71% for the HCV patients without HCC (p=0.0005). In an intention-to-treat analysis (from time of acceptance to the waiting list) HCV was also associated with an impaired survival. CONCLUSIONS: HCV cirrhosis, which is now also an important indication for LTX in the Nordic countries, and significantly impairs survival following LTX. Concomitant HCC and donor age are the two most important factors contributing to an impaired survival.
Nyckelord
- Adult
- Carcinoma
- Hepatocellular
- etiology
- mortality
- Case-Control Studies
- Comorbidity
- Female
- Hepatitis C
- complications
- etiology
- mortality
- Humans
- Liver Cirrhosis
- Liver Transplantation
- adverse effects
- mortality
- Male
- Middle Aged
- Scandinavia
- epidemiology
- Survival Rate
- hepatitis C
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Melum, Espen
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Friman, Styrbjör ...
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Bjøro, Kristian
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Rasmussen, Allan
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Isoniemi, Helena
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Gjertsen, Henrik
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visa fler...
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Bäckman, Lars, 1 ...
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Oksanen, Antti
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Olausson, Michae ...
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Duraj, Frans
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Ericzon, Bo-Göra ...
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visa färre...
- Artiklar i publikationen
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Journal of hepat ...
- Av lärosätet
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Göteborgs universitet
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Uppsala universitet
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Karolinska Institutet