Sökning: onr:"swepub:oai:gup.ub.gu.se/75036" > How quantitative me...
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000 | 02808naa a2200349 4500 | |
001 | oai:gup.ub.gu.se/75036 | |
003 | SwePub | |
008 | 240528s2008 | |||||||||||000 ||eng| | |
009 | oai:research.chalmers.se:91a70ad7-1cf6-4736-8abe-2e17d454cba5 | |
024 | 7 | a https://gup.ub.gu.se/publication/750362 URI |
024 | 7 | a https://doi.org/10.1016/j.jtbi.2008.04.0372 DOI |
024 | 7 | a https://research.chalmers.se/publication/750362 URI |
040 | a (SwePub)gud (SwePub)cth | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Frey, Simone4 aut |
245 | 1 0 | a How quantitative measures unravel design principles in multi-stage phosphorylation cascades. |
264 | 1 | b Elsevier BV,c 2008 |
520 | a We investigate design principles of linear multi-stage phosphorylation cascades by using quantitative measures for signaling time, signal duration and signal amplitude. We compare alternative pathway structures by varying the number of phosphorylations and the length of the cascade. We show that a model for a weakly activated pathway does not reflect the biological context well, unless it is restricted to certain parameter combinations. Focusing therefore on a more general model, we compare alternative structures with respect to a multivariate optimization criterion. We test the hypothesis that the structure of a linear multi-stage phosphorylation cascade is the result of an optimization process aiming for a fast response, defined by the minimum of the product of signaling time and signal duration. It is then shown that certain pathway structures minimize this criterion. Several popular models of MAPK cascades form the basis of our study. These models represent different levels of approximation, which we compare and discuss with respect to the quantitative measures. | |
650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
700 | 1 | a Millat, Thomas4 aut |
700 | 1 | a Hohmann, Stefan,d 1956u Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,University of Gothenburg4 aut0 (Swepub:cth)hohmann |
700 | 1 | a Wolkenhauer, Olaf4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för cell- och molekylärbiologi4 org |
773 | 0 | t Journal of theoretical biologyd : Elsevier BVg 254:1, s. 27-36q 254:1<27-36x 1095-8541x 0022-5193 |
856 | 4 | u http://dx.doi.org/10.1016/j.jtbi.2008.04.037y FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/75036 |
856 | 4 8 | u https://doi.org/10.1016/j.jtbi.2008.04.037 |
856 | 4 8 | u https://research.chalmers.se/publication/75036 |
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