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Reduced bone minera...
Reduced bone mineral density and radial bone growth in young rabbits treated with dexamethasone eye drops.
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- Kugelberg, Maria (författare)
- Karolinska Institutet
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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- Sävendahl, Lars (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2005-06-13
- 2005
- Engelska.
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Ingår i: Hormone research. - : S. Karger AG. - 0301-0163. ; 63:4, s. 165-70
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To investigate the effect of dexamethasone eye drops on bone metabolism in newborn rabbits. METHODS: Thirty-four 3-week-old rabbits had unilateral clear lens extraction and were randomized into three groups. Postoperatively, group 1 received high-dose and group 2 low-dose dexamethasone eye drops (average doses 0.27 and 0.10 mg/kg body weight/day, respectively). These rabbits also received a postoperative subconjunctival injection of betamethasone. Group 3 (control) received vehicle eye drops only. After 8 weeks of treatment, all animals were killed and the left femurs were isolated and subjected to peripheral quantitative computerized tomography (pQCT) and dual X-ray absorptiometry (DXA) analyses. RESULTS: DXA showed that rabbits treated with either a high or low dose of dexamethasone eye drops had significantly reduced areal bone mineral density (BMD), area and total bone mineral content (BMC) of the femur. Measurements with pQCT demonstrated a dose-dependent reduction in cortical BMC, cortical volumetric BMD and cortical area. These effects were associated with an inhibition of radial femur growth, cortical thickness and periosteal and endosteal circumferences. CONCLUSION: Dexamethasone eye drops have systemic effects affecting several bone parameters in young rabbits. Any long-term systemic effects of ocular glucocorticoids need to be further studied.
Nyckelord
- Animals
- Anti-Inflammatory Agents
- administration & dosage
- adverse effects
- Bone Density
- drug effects
- Bone Development
- drug effects
- Dexamethasone
- administration & dosage
- adverse effects
- Dose-Response Relationship
- Drug
- Injections
- Subcutaneous
- Rabbits
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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