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Estrogen receptor (...
Estrogen receptor (ER)-beta reduces ERalpha-regulated gene transcription, supporting a "ying yang" relationship between ERalpha and ERbeta in mice.
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- Lindberg, Marie K, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Movérare, Sofia (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Skrtic, Stanko, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi,Institute of Internal Medicine, Dept of Clinical Pharmacology
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- Gao, Hui-Ling (författare)
- Karolinska Institutet
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- Dahlman-Wright, Karin (författare)
- Karolinska Institutet
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- Gustafsson, Jan-Ake (författare)
- Karolinska Institutet
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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(creator_code:org_t)
- The Endocrine Society, 2003
- 2003
- Engelska.
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Ingår i: Molecular endocrinology (Baltimore, Md.). - : The Endocrine Society. - 0888-8809 .- 1944-9917. ; 17:2, s. 203-8
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Abstract
Ämnesord
Stäng
- Estrogen is of importance for the regulation of adult bone metabolism. The aim of the present study was to determine the role of estrogen receptor-beta (ERbeta) in vivo on global estrogen-regulated transcriptional activity in bone. The effect of estrogen in bone of ovariectomized mice was determined using microarray analysis including 9400 genes. Most of the genes (95% = 240 genes) that were increased by estrogen in wild-type (WT) mice were also increased by estrogen in ERbeta-inactivated mice. Interestingly, the average stimulatory effect of estrogen on the mRNA levels of these genes was 85% higher in ERbeta-inactivated than in WT mice, demonstrating that ERbeta reduces estrogen receptor-alpha (ERalpha)-regulated gene transcription in bone. The average stimulatory effect of estrogen on estrogen-regulated bone genes in ERalpha-inactivated mice was intermediate between that seen in WT and ERalphabeta double-inactivated mice. Thus, ERbeta inhibits ERalpha-mediated gene transcription in the presence of ERalpha, whereas, in the absence of ERalpha, it can partially replace ERalpha. In conclusion, our in vivo data indicate that an important physiological role of ERbeta is to modulate ERalpha-mediated gene transcription supporting a "Ying Yang" relationship between ERalpha and ERbeta in mice.
Nyckelord
- Animals
- Bone and Bones
- drug effects
- physiology
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Estrogens
- pharmacology
- Female
- Gene Expression Regulation
- drug effects
- Liver
- drug effects
- physiology
- Male
- Mice
- Mice
- Mutant Strains
- Oligonucleotide Array Sequence Analysis
- Ovariectomy
- Receptors
- Estrogen
- genetics
- metabolism
- Transcription
- Genetic
- physiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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