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Abstract Ämnesord
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  • The immune-modulating cytokine interleukin-6 (IL-6) is expressed both in adipose tissue and centrally in hypothalamic nuclei that regulate body composition. We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement. The obese Il6-/- mice had disturbed carbohydrate and lipid metabolism, increased leptin levels and decreased responsiveness to leptin treatment. To investigate the possible mechanism and site of action of the anti-obesity effect of IL-6, we injected rats centrally and peripherally with IL-6 at low doses. Intracerebroventricular, but not intraperitoneal IL-6 treatment increased energy expenditure. In conclusion, centrally acting IL-6 exerts anti-obesity effects in rodents.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)

Nyckelord

Age Factors
Animals
Blood Glucose
analysis
Body Composition
Corticosterone
blood
Eating
physiology
Energy Metabolism
physiology
Female
Glucose Tolerance Test
Injections
Intraventricular
Interleukin-6
deficiency
genetics
pharmacology
Leptin
blood
Lipids
blood
Male
Mice
Mice
Mutant Strains
Obesity
etiology
genetics
Sex Factors

Publikations- och innehållstyp

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