Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism.

• IGF-I is important for postnatal body growth and exhibits insulin-like effects on carbohydrate metabolism. The function of liver-derived IGF-I is still not established, although we previously demonstrated that liver-derived IGF-I is not required for postnatal body growth. Mice whose IGF-I gene in the liver was inactivated at 24 days of age were used to investigate the long-term role of liver-derived IGF-I for carbohydrate and lipid metabolism. Serum levels of leptin in these mice were increased by >100% at 3 months of age, whereas the fat mass of the mice was decreased by 25% at 13 months of age. The mice became markedly hyperinsulinemic and yet normoglycemic, indicating an adequately compensated insulin resistance. Furthermore, they had increased serum levels of cholesterol. We conclude that liver-derived IGF-I is of importance for carbohydrate and lipid metabolism.

Nyckelord

Absorptiometry

Photon

Animals

Blood Glucose

metabolism

Body Composition

genetics

Chimera

Cholesterol

blood

Dietary Carbohydrates

metabolism

Dietary Fats

metabolism

Female

Gene Silencing

Insulin

blood

Insulin Resistance

genetics

Insulin-Like Growth Factor I

genetics

physiology

Lipid Metabolism

Liver

chemistry

Male

Mice

Mice

Inbred C57BL

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)