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Possible roles of i...
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Skrtic, Stanko,1970Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi,Institute of Internal Medicine, Dept of Clinical Pharmacology
(författare)
Possible roles of insulin-like growth factor in regulation of physiological and pathophysiological liver growth.
- Artikel/kapitelEngelska2001
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LIBRIS-ID:oai:gup.ub.gu.se/75384
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https://gup.ub.gu.se/publication/75384URI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BACKGROUND/AIMS: Almost all circulating insulin-like growth factor-1 (IGF-1) is produced and secreted from the liver. However, the possible role of IGF-1 in local regulation of liver functions including liver growth is unclear. In the present study, we investigated the role of IGF-1 on liver growth in vivo and in hepatic stellate cell function in vitro. RESULTS: Liver-specific knock-out of the IGF-1 gene by use of the cre-loxP system caused enhanced liver growth, possibly reflecting increased growth hormone (GH) secretion due to decreased negative feedback by IGF-1. Studies on cultured rat hepatic stellate cells (HSC) showed that IGF-1 and hepatocyte-conditioned medium (PCcM) time- and dose-dependently increased hepatocyte growth factor (HGF) mRNA and HGF immunoreactivity. IGF-1 and PCcM also enhanced DNA synthesis in the HSC cultures. The PCcM did not contain bioactive IGF-1 and was also able to stimulate proliferation when prepared under serum- and hormone-free conditions. CONCLUSION: In vivo results show that IGF-1 is not essential for normal growth of the intact liver. The in vitro results indicate that both IGF-1 and IGF- 1-independent factor(s) from hepatocytes can stimulate HGF production by HSC. It remains to be investigated whether these effects are of importance for liver regeneration or pathological conditions.
Ämnesord och genrebeteckningar
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Animals
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Cell Division
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physiology
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Culture Media
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Conditioned
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pharmacology
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DNA
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biosynthesis
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Hepatocyte Growth Factor
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biosynthesis
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genetics
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Hepatocytes
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cytology
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pathology
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Liver
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cytology
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growth & development
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metabolism
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pathology
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Liver Diseases
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physiopathology
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Mice
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Mice
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Knockout
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genetics
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Mitogens
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pharmacology
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Somatomedins
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deficiency
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physiology
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wallenius, Kristina,1973Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
(författare)
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Sjögren, Klara,1970Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xsjokl
(författare)
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Isaksson, Olle,1943Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xisaol
(författare)
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Ohlsson, Claes,1965Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine(Swepub:gu)xohlcl
(författare)
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Jansson, John-Olov,1954Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine(Swepub:gu)xjanjo
(författare)
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Göteborgs universitetInstitutionen för invärtesmedicin, Avdelningen för klinisk farmakologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Hormone research55 Suppl 1, s. 1-60301-0163
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Skrtic, Stanko, ...
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Wallenius, Krist ...
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Sjögren, Klara, ...
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Isaksson, Olle, ...
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Ohlsson, Claes, ...
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Jansson, John-Ol ...
- Artiklar i publikationen
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Hormone research
- Av lärosätet
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Göteborgs universitet