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Environmental salin...
Environmental salinity regulates receptor expression, cellular effects, and circulating levels of two antagonizing hormones, 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3, in rainbow trout.
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Larsson, D (författare)
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Nemere, Ilka (författare)
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Aksnes, Lage (författare)
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visa fler...
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- Sundell, Kristina, 1959 (författare)
- Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology
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visa färre...
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: Endocrinology. - 0013-7227. ; 144:2, s. 559-66
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- In freshwater-adapted rainbow trout, intestinal cells (enterocytes) possess receptors for 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] in the basolateral membrane, and respond to treatment with 1,25(OH)(2)D(3) with increased intracellular calcium concentrations. No receptors are found for the antagonizing hormone 24,25-dihydroxyvitamin D(3) [24,25(OH)(2)D(3)] at the enterocyte basolateral membrane, and it has no effect on enterocyte calcium homeostasis. After acclimation to seawater, however, the enterocyte membrane receptors for 1,25(OH)(2)D(3) are down-regulated and specific binding for 24,25(OH)(2)D(3) appears, which is further up-regulated with time spent in seawater. This shift in receptor expression is concurrent with an increased sensitivity of the enterocytes to 24,25(OH)(2)D(3) and a decreased sensitivity to 1,25(OH)(2)D(3). This results in a partial inhibition of intracellular calcium uptake, which would be beneficial when inhabiting a calcium-rich environment like seawater.
Ämnesord
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
Nyckelord
- 24
- 25-Dihydroxyvitamin D 3
- blood
- Adaptation
- Physiological
- physiology
- Animals
- Calcitriol
- blood
- Calcium
- metabolism
- Cell Membrane
- metabolism
- Enterocytes
- metabolism
- Environment
- Female
- Fresh Water
- Homeostasis
- physiology
- Male
- Oncorhynchus mykiss
- physiology
- Receptors
- Calcitriol
- metabolism
- Seawater
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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