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Environmental salin...
Environmental salinity regulates receptor expression, cellular effects, and circulating levels of two antagonizing hormones, 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3, in rainbow trout.
- Artikel/kapitelEngelska2003
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LIBRIS-ID:oai:gup.ub.gu.se/76311
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https://gup.ub.gu.se/publication/76311URI
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Ämneskategori:art swepub-publicationtype
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In freshwater-adapted rainbow trout, intestinal cells (enterocytes) possess receptors for 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] in the basolateral membrane, and respond to treatment with 1,25(OH)(2)D(3) with increased intracellular calcium concentrations. No receptors are found for the antagonizing hormone 24,25-dihydroxyvitamin D(3) [24,25(OH)(2)D(3)] at the enterocyte basolateral membrane, and it has no effect on enterocyte calcium homeostasis. After acclimation to seawater, however, the enterocyte membrane receptors for 1,25(OH)(2)D(3) are down-regulated and specific binding for 24,25(OH)(2)D(3) appears, which is further up-regulated with time spent in seawater. This shift in receptor expression is concurrent with an increased sensitivity of the enterocytes to 24,25(OH)(2)D(3) and a decreased sensitivity to 1,25(OH)(2)D(3). This results in a partial inhibition of intracellular calcium uptake, which would be beneficial when inhabiting a calcium-rich environment like seawater.
Ämnesord och genrebeteckningar
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NATURVETENSKAP Biologi Zoologi hsv//swe
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NATURAL SCIENCES Biological Sciences Zoology hsv//eng
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24
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25-Dihydroxyvitamin D 3
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blood
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Adaptation
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Physiological
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physiology
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Animals
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Calcitriol
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blood
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Calcium
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metabolism
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Cell Membrane
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metabolism
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Enterocytes
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metabolism
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Environment
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Female
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Fresh Water
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Homeostasis
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physiology
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Male
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Oncorhynchus mykiss
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physiology
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Receptors
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Calcitriol
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metabolism
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Seawater
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nemere, Ilka
(författare)
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Aksnes, Lage
(författare)
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Sundell, Kristina,1959Gothenburg University,Göteborgs universitet,Zoologiska institutionen,Department of Zoology(Swepub:gu)xskris
(författare)
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Göteborgs universitetZoologiska institutionen
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Endocrinology144:2, s. 559-660013-7227
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