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Partial neuroprotec...
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Dean, Justin MGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
(författare)
Partial neuroprotection with low-dose infusion of the alpha2-adrenergic receptor agonist clonidine after severe hypoxia in preterm fetal sheep.
- Artikel/kapitelEngelska2008
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LIBRIS-ID:oai:gup.ub.gu.se/78751
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https://gup.ub.gu.se/publication/78751URI
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https://doi.org/10.1016/j.neuropharm.2008.05.009DOI
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We have previously shown that brief alpha(2)-adrenergic receptor blockade increased neuronal injury after severe hypoxia in preterm fetal sheep. We now examine whether infusion of an alpha(2)-adrenergic receptor agonist, clonidine, is neuroprotective. Preterm fetal sheep (70% gestation) received either saline-vehicle or clonidine at either 10 microg/kg/h (low-dose) or 100 microg/kg/h (high-dose) from 15 min until 4 h after 25 min of umbilical cord occlusion. Both low- and high-dose clonidine infusions after sham-occlusion were associated with transient EEG suppression but no neuronal loss. Low-dose but not high-dose clonidine infusions after umbilical cord occlusion were associated with a significant overall increase in numbers of surviving neurons after three days' recovery. High-dose clonidine was associated with transient hyperglycemia and increased numbers of delayed electrographic seizures. These results provide further evidence that alpha(2)-adrenergic receptor activation shortly after perinatal hypoxia-ischemia can promote neural recovery, but highlight the complex dose-response of exogenous therapy.
Ämnesord och genrebeteckningar
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Cerebral palsy; cold extremities; pain; constipation; sleeping disorders; well-being
Biuppslag (personer, institutioner, konferenser, titlar ...)
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George, Sherly
(författare)
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Naylor, Andrew Stuart,1977
(författare)
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Mallard, Carina,1963Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xmallc
(författare)
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Gunn, Alistair J
(författare)
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Bennet, Laura
(författare)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för fysiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neuropharmacology: Elsevier BV55:2, s. 166-740028-3908
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