Sökning: onr:"swepub:oai:gup.ub.gu.se/78823" >
Amyloid-related bio...
-
Andreasen, NielsKarolinska Institutet
(författare)
Amyloid-related biomarkers for Alzheimer's disease.
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
-
Bentham Science Publishers Ltd.2008
Nummerbeteckningar
-
LIBRIS-ID:oai:gup.ub.gu.se/78823
-
https://gup.ub.gu.se/publication/78823URI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:116845548URI
-
https://doi.org/10.2174/092986708783955572DOI
Kompletterande språkuppgifter
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:for swepub-publicationtype
Anmärkningar
-
Alzheimer's disease (AD) is an age-related disorder that causes brain damage resulting in progressive cognitive impairment and death. Three decades of progress have given us a detailed understanding of the underlying molecular mechanisms. Over the past 10 years, this knowledge has translated into a range of targets for therapy, the most promising of which is amyloid beta (Abeta). An imbalance between the production and clearance of Abeta is thought by many to represent the earliest event in the pathogenesis of AD. Abeta is known to be subject to oligomerisation, a process that increases its synaptotoxicity. The oligomers may aggregate further to proto-fibrils and fibrils, eventually forming senile plaques, the neuropathological hallmark of AD. In this article we review the key aspects of Abeta as a biomarker for AD, including its pathogenicity, the diagnostic performance of different Abeta assays in different settings, and the potential usefulness of Abeta as a surrogate marker for treatment efficacy in clinical trials of novel Abeta-targeting drugs.
Ämnesord och genrebeteckningar
-
Alzheimer Disease
-
metabolism
-
pathology
-
Amyloid beta-Protein
-
metabolism
-
Animals
-
Biological Markers
-
metabolism
-
Humans
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe
(författare)
-
Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Current medicinal chemistry: Bentham Science Publishers Ltd.15:8, s. 766-710929-8673
Internetlänk
Hitta via bibliotek
Till lärosätets databas