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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02819naa a2200397 4500 | |
| 001 | oai:gup.ub.gu.se/78823 | |
| 003 | SwePub | |
| 008 | 240528s2008 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:116845548 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/788232 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1168455482 URI |
| 024 | 7 | a https://doi.org/10.2174/0929867087839555722 DOI |
| 040 | a (SwePub)gud (SwePub)ki | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a for2 swepub-publicationtype |
| 100 | 1 | a Andreasen, Nielsu Karolinska Institutet4 aut |
| 245 | 1 0 | a Amyloid-related biomarkers for Alzheimer's disease. |
| 264 | 1 | b Bentham Science Publishers Ltd.c 2008 |
| 520 | a Alzheimer's disease (AD) is an age-related disorder that causes brain damage resulting in progressive cognitive impairment and death. Three decades of progress have given us a detailed understanding of the underlying molecular mechanisms. Over the past 10 years, this knowledge has translated into a range of targets for therapy, the most promising of which is amyloid beta (Abeta). An imbalance between the production and clearance of Abeta is thought by many to represent the earliest event in the pathogenesis of AD. Abeta is known to be subject to oligomerisation, a process that increases its synaptotoxicity. The oligomers may aggregate further to proto-fibrils and fibrils, eventually forming senile plaques, the neuropathological hallmark of AD. In this article we review the key aspects of Abeta as a biomarker for AD, including its pathogenicity, the diagnostic performance of different Abeta assays in different settings, and the potential usefulness of Abeta as a surrogate marker for treatment efficacy in clinical trials of novel Abeta-targeting drugs. | |
| 653 | a Alzheimer Disease | |
| 653 | a metabolism | |
| 653 | a pathology | |
| 653 | a Amyloid beta-Protein | |
| 653 | a metabolism | |
| 653 | a Animals | |
| 653 | a Biological Markers | |
| 653 | a metabolism | |
| 653 | a Humans | |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 710 | 2 | a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
| 773 | 0 | t Current medicinal chemistryd : Bentham Science Publishers Ltd.g 15:8, s. 766-71q 15:8<766-71x 0929-8673 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/78823 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:116845548 |
| 856 | 4 8 | u https://doi.org/10.2174/092986708783955572 |
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