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Circulating osteopr...
Circulating osteoprotegerin levels and long-term prognosis in patients with acute coronary syndromes.
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Omland, Torbjörn (författare)
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Ueland, Thor (författare)
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- Jansson, Anna M (författare)
- Karolinska Institutet
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Persson, Anita (författare)
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- Karlsson, Thomas, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Extern,Institute of Medicine, Department of Molecular and Clinical Medicine,External
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Smith, Camilla (författare)
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- Herlitz, Johan, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,[external]
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Aukrust, Pål (författare)
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- Hartford, Marianne, 1944 (författare)
- Gothenburg University,Göteborgs universitet,Extern,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,External,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Caidahl, Kenneth, 1949 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Extern,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,External,Institute of Medicine, Department of Molecular and Clinical Medicine
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 51:6, s. 627-33
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Abstract
Ämnesord
Stäng
- OBJECTIVES: This study was designed to assess the association between osteoprotegerin (OPG) levels on admission and long-term prognosis in patients with acute coronary syndromes (ACS). BACKGROUND: Osteoprotegerin, a member of the tumor necrosis factor receptor superfamily, has pleiotropic effects on bone metabolism, endocrine function, and the immune system. METHODS: Serum samples for OPG analysis were obtained within 24 h of admission in 897 ACS patients (median age 66 years, 71% men) and related to the incidence of death, heart failure (HF) hospitalizations, myocardial infarction (MI), and stroke. RESULTS: A total of 261 patients died during a median follow-up of 89 months. The baseline OPG concentration was strongly associated with increased long-term mortality (hazard ratio [HR] for HR per 1 SD increase in logarithmically transformed OPG level 1.7 [range 1.5 to 1.9] p < 0.0001) and HF hospitalizations (HR 2.0 [range 1.6 to 2.5]; p < 0.0001) but weaker with recurrent MI (HR 1.3 [range 1.0 to 1.5]; p = 0.02) and not with stroke (HR 1.2 [range 0.9 to 1.6]; p = 0.35). After adjustment for conventional risk markers, including troponin I, C-reactive protein (CRP), B-type natriuretic peptide (BNP), and ejection fraction, the association remained significant for mortality (HR 1.4 [range 1.2 to 1.7]; p < 0.0001) and HF hospitalization (HR 1.6 [range 1.2 to 2.1]; p = 0.0002), but not recurrent MI. By comparison of the area under the receiver-operating characteristics curves, OPG performed similarly to BNP and ejection fraction and significantly better than CRP and troponin I as a predictor of death. CONCLUSIONS: Serum OPG is strongly predictive of long-term mortality and HF development in patients with ACS, independent of conventional risk markers.
Nyckelord
- Acute Coronary Syndrome
- mortality
- physiopathology
- Aged
- Angina
- Unstable
- mortality
- physiopathology
- Biological Markers
- Bone and Bones
- metabolism
- Endocrine System
- Female
- Hospitalization
- Humans
- Immune System
- Incidence
- Male
- Middle Aged
- Osteoprotegerin
- physiology
- Prognosis
- Prospective Studies
- Time Factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Omland, Torbjörn
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Ueland, Thor
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Jansson, Anna M
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Persson, Anita
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Karlsson, Thomas ...
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Smith, Camilla
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visa fler...
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Herlitz, Johan, ...
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Aukrust, Pål
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Hartford, Marian ...
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Caidahl, Kenneth ...
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- Artiklar i publikationen
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Journal of the A ...
- Av lärosätet
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Göteborgs universitet
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Karolinska Institutet
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Högskolan i Borås