Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum.

The striatum is a critical structure for the control of voluntary behaviour, and striatal synaptic plasticity has been implicated in instrumental learning. As ethanol consumption can cause impairments in cognition, learning, and action selection, it is important to understand the effects of this drug on striatal function. In this study we examined the effects of ethanol on long-term synaptic plasticity in the dorsomedial striatum (DMS), a striatal subregion that plays a central role in the acquisition and selection of goal-directed actions. Ethanol was found to impair N-methyl-d-aspartic acid receptor (NMDAR)-dependent long-term potentiation (LTP) dose-dependently in the DMS, and to promote long-term depression (LTD) at the highest concentration (50 mm) used. These results suggest that ethanol, at a concentration usually associated with mild intoxication, could significantly change experience-dependent modification of corticostriatal circuits underlying the learning of goal-directed instrumental actions.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
Animals
Animals
Newborn
Central Nervous System Depressants
pharmacology
Corpus Striatum
cytology
Dopamine Antagonists
pharmacology
Dose-Response Relationship
Drug
Dose-Response Relationship
Radiation
Electric Stimulation
Ethanol
pharmacology
Evoked Potentials
drug effects
physiology
radiation effects
Neuronal Plasticity
drug effects
Neurons
drug effects
physiology
Patch-Clamp Techniques
methods
Piperidines
pharmacology
Pyrazoles
pharmacology
Rats
Rats
Sprague-Dawley
Sulpiride
pharmacology
Synaptic Transmission
drug effects
physiology
Time Factors

Park, Brian S (författare)
Adermark, Louise,1974Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xadelo (författare)
Lovinger, David M (författare)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Ingår i:The European journal of neuroscience: Wiley25:11, s. 3226-320953-816X1460-9568

Av författaren/redakt...: Yin, Henry H; Park, Brian S; Adermark, Louise ...; Lovinger, David ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Fysiologi

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