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Iodine content and ...
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Hansson, Marie,1979Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Institutionen för kliniska vetenskaper,Department of Physics (GU),Institute of Clinical Sciences
(författare)
Iodine content and distribution in extratumoral and tumor thyroid tissue analyzed with X-ray fluorescence and time-of-flight secondary ion mass spectrometry.
- Artikel/kapitelEngelska2008
Förlag, utgivningsår, omfång ...
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Mary Ann Liebert Inc,2008
Nummerbeteckningar
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LIBRIS-ID:oai:gup.ub.gu.se/82651
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https://gup.ub.gu.se/publication/82651URI
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https://doi.org/10.1089/thy.2008.0020DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: The thyroid's ability to enrich and store iodine has implications for thyroid cancer genesis, progression, and treatment. The study objective was to investigate thyroid iodine content (TIC) in tumoral and extratumoral tissue in patients with papillary thyroid cancer (PTC) as opposed to thyroid healthy controls using two different techniques: X-ray fluorescence (XRF) and time-of-flight secondary ion mass spectrometry (TOF-SIMS). METHODS: Tissue samples from 10 patients with normal thyroids and 7 patients with PTC were collected. TIC was quantified with XRF, and the iodine stores were located on a histological level with TOF-SIMS. RESULTS: Mean TIC in controls was 0.6 mg/mL (range 0.3-1.2 mg/mL). For the cancer patients, the mean TIC was 0.8 mg/mL (range 0.2-2.3 mg/mL) in extratumoral thyroid tissue, but no iodine was detected in the tumors. TOF-SIMS investigation of the PTC patients showed significantly higher TIC in extratumoral tissue than in tumoral tissue. Iodine in the extratumoral tissue was predominantly located in the follicle lumen with a variation in concentration among follicles. CONCLUSIONS: XRF and TOF-SIMS are two complementary methods for obtaining insight into content and localization of iodine in the thyroid. XRF can be used in vitro or in vivo on a large number of samples or patients, respectively. TOF-SIMS on the other hand provides detailed images of the iodine location. The combined information from the two methods is of value for further studies on iodine metabolism in thyroid malignancy.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Grunditz, Torsten,1945Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xgruto
(författare)
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Isaksson, Mats,1961Gothenburg University,Göteborgs universitet,Institutionen för fysik (GU),Institutionen för kliniska vetenskaper,Department of Physics (GU),Institute of Clinical Sciences(Swepub:gu)xmatis
(författare)
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Jansson, Svante,1948Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xjanss
(författare)
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Lausmaa, Jukka
(författare)
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Mölne, Johan,1958Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology(Swepub:gu)xmolnj
(författare)
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Berg, Gertrud,1944Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xbeger
(författare)
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Göteborgs universitetInstitutionen för fysik (GU)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Thyroid : official journal of the American Thyroid Association: Mary Ann Liebert Inc18:11, s. 1215-201557-9077
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Ingår i:Thyroid: Mary Ann Liebert Inc18:11, s. 1215-201050-7256
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Hansson, Marie, ...
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Grunditz, Torste ...
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Isaksson, Mats, ...
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Jansson, Svante, ...
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Lausmaa, Jukka
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Mölne, Johan, 19 ...
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Berg, Gertrud, 1 ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Thyroid : offici ...
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Thyroid
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Göteborgs universitet