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Dendritic morpholog...
Dendritic morphology in epileptogenic cortex from TRPE patients, revealed by intracellular Lucifer Yellow microinjection and confocal laser scanning microscopy.
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Belichenko, P (författare)
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- Sourander, P (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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- Malmgren, Kristina, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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- Nordborg, Claes, 1946 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin , Avdelningen för patologi,Institute of Laboratory Medicine, Dept of Pathology
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von Essen, C (författare)
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- Rydenhag, Bertil, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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Lindström, S (författare)
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- Hedström, Anders (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för klinisk neurovetenskap,Institute of Clinical Neurosciences
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- Uvebrant, Paul, 1951 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Dahlström, Annica, 1941 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology
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(creator_code:org_t)
- 1994
- 1994
- Engelska.
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Ingår i: Epilepsy research. - 0920-1211. ; 18:3, s. 233-47
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- Biopsy material was obtained from cortical epileptogenic zones (eight temporal, one occipital, one parietal and one frontal) of eleven patients aged 1.5-47 years with therapy-resistant partial epilepsy (TRPE) undergoing epilepsy surgery. Control autopsy material (two temporal, two occipital, one parietal and one frontal) was removed from six neurologically healthy cases within 6-10 hours postmortem delay. In each specimen, 100-300 pyramidal and non-pyramidal neurons were visualized by intracellular Lucifer Yellow microinjection. Single neurons were imaged using CLSM generated serial optical sections; 2-D reconstruction of each neuron was made using z-projection of serial optical images, and 3-D reconstructions and rotations were computerized. Neuronal maps from TRPE biopsies, compared to control autopsies, show markedly increased numbers of dendritic abnormalities of single pyramidal and non-pyramidal neurons in layers I, II-III, V-VII, and in the subcortical white matter. The abnormalities include: (1) increased number of non-pyramidal cells in layer I; (2) many pyramidal cells with two or three dendrites originating apically, rather than one single apical dendrite, in layers II-III; (3) atypical orientation of oblique apical and basal dendrites in pyramidal neurons of layers II-VII; (4) increased number of atypical 'dinosaur-like' and fusiform cells in layers V-VII; (5) numerous neurons in the white matter. These abnormalities may be etiological in cases with early onset, and predisposing in cases with late onset.
Nyckelord
- Adolescent
- Adult
- Cerebral Cortex
- pathology
- Child
- Child
- Preschool
- Dendrites
- ultrastructure
- Drug Resistance
- Electroencephalography
- Epilepsies
- Partial
- pathology
- Female
- Humans
- Image Processing
- Computer-Assisted
- Isoquinolines
- Magnetic Resonance Imaging
- Male
- Microinjections
- Microscopy
- Confocal
- Middle Aged
- Pyramidal Cells
- ultrastructure
- Tomography
- X-Ray Computed
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Belichenko, P
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Sourander, P
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Malmgren, Kristi ...
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Nordborg, Claes, ...
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von Essen, C
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Rydenhag, Bertil ...
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visa fler...
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Lindström, S
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Hedström, Anders
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Uvebrant, Paul, ...
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Dahlström, Annic ...
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visa färre...
- Artiklar i publikationen
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Epilepsy researc ...
- Av lärosätet
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Göteborgs universitet