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Disease burden due ...
Disease burden due to enterotoxigenic Escherichia coli in the first 2 years of life in an urban community in Bangladesh.
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Qadri, Firdausi (författare)
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Saha, Amit (författare)
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Ahmed, Tanvir, 1970 (författare)
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Al Tarique, Abdullah (författare)
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Begum, Yasmin Ara (författare)
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- Svennerholm, Ann-Mari, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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(creator_code:org_t)
- 2007
- 2007
- Engelska.
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Ingår i: Infection and immunity. - 0019-9567. ; 75:8, s. 3961-8
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A cohort of 321 children was followed from birth up to 2 years of age to determine the incidence of enterotoxigenic Escherichia coli (ETEC) in Bangladesh. The average number of diarrheal days and incidence rates were 6.6 and 2.3/child/year, respectively. ETEC was the most common pathogen and was isolated in 19.5% cases, with an incidence of 0.5 episode/child/year. The prevalence of rotavirus diarrhea was lower (10%). ETEC expressing the heat-stable enterotoxin (ST) was predominant. Strains isolated from diarrheal cases were positive for colonization factors (CFs) in higher frequency (66%) than from healthy children (33%) (P < 0.001). The heat-labile toxin (LT)-positive strains from healthy children were more often CF negative (92%) than those isolated from children with diarrhea (73%) (P < 0.001). In children with symptomatic or asymptomatic infections by CFA/I, CS1 plus CS3, CS2 plus CS3, or CS5 plus CS6 strains, a repeat episode of diarrhea or infection by the homologous CF type was uncommon. Repeat symptomatic infections were noted mostly for LT- and ST-expressing ETEC. ETEC diarrhea was more prevalent in children in the A and AB groups than in those in the O blood group (P = 0.032 to 0.023). Children with ETEC diarrhea were underweight and growth stunted at the 2-year follow-up period, showing the importance of strategies to prevent and decrease ETEC diarrheal morbidity in children.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- ABO Blood-Group System
- Bacterial Toxins
- biosynthesis
- Bangladesh
- epidemiology
- Breast Feeding
- Diarrhea
- Infantile
- epidemiology
- microbiology
- Enterotoxins
- biosynthesis
- Enzyme-Linked Immunosorbent Assay
- Escherichia coli
- classification
- isolation & purification
- Escherichia coli Infections
- blood
- epidemiology
- microbiology
- pathology
- Escherichia coli Proteins
- biosynthesis
- Feces
- microbiology
- Female
- Humans
- Incidence
- Infant
- Infant
- Newborn
- Male
- Pregnancy
- Rotavirus
- isolation & purification
- Rotavirus Infections
- epidemiology
- Seasons
- Urban Population
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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