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The CHARM program: ...
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Hennekens, C. H.
(författare)
The CHARM program: study design leads to findings of clinical and public health importance
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2016-06-29
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SAGE Publications,2007
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LIBRIS-ID:oai:gup.ub.gu.se/85413
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https://gup.ub.gu.se/publication/85413URI
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https://doi.org/10.1177/1074248407301131DOI
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In large-scale randomized trials and their meta-analyses, beta-adrenergic blockers and angiotensin-converting enzyme inhibitors provide statistically significant and clinically important additive mortality and morbidity benefits in the treatment of heart failure. The CHARM trials were designed to test whether the angiotensin-receptor blocker candesartan would provide statistically significant and clinically important additive mortality and morbidity benefits to patients with heart failure as an alternative or in addition to angiotensin-converting enzyme inhibitors. CHARM demonstrated that an angiotensin-receptor blocker at a proven dose is an effective and safe therapy as an alternative or in addition to angiotensin-converting enzyme inhibitors in patients with heart failure, 55% of whom were receiving beta-adrenergic blockers. These benefits include reductions in cardiovascular mortality rate as well as in hospitalization for heart failure. Such patients have a 50% mortality rate at 5 years, and heart failure is the leading cause of hospitalization for patients 65 years of age and older.
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Pfeffer, M. A.
(författare)
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Swedberg, Karl,1944Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine(Swepub:gu)xsweka
(författare)
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Göteborgs universitetInstitutionen för medicin, avdelningen för akut och kardiovaskulär medicin
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:J Cardiovasc Pharmacol Ther: SAGE Publications12:2, s. 124-61074-2484
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Ingår i:Journal of Cardiovascular Pharmacology and Therapeutics: SAGE Publications12:2, s. 124-61940-4034
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