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Genetic analyses of...
Genetic analyses of the role of RCE1 in RAS membrane association and transformation.
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- Bergö, Martin, 1970 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Wallenberglaboratoriet,Institute of Medicine, Department of Internal Medicine,Wallenberg Laboratory
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- Wahlström, Annika, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Fong, Loren G. (författare)
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Young, Stephen G (författare)
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(creator_code:org_t)
- 2008
- 2008
- Engelska.
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Ingår i: Methods in enzymology. - 0076-6879. ; 438, s. 367-89
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Proteins terminating with a CAAX motif, such as the nuclear lamins and the RAS family of proteins, undergo post-translational modification of a carboxyl-terminal cysteine with an isoprenyl lipid--a process called protein prenylation. After prenylation, the last three residues of CAAX proteins are clipped off by an endoprotease of the endoplasmic reticulum. RCE1 is responsible for the endoproteolytic processing of the RAS proteins and is likely responsible for endoproteolytic processing of the vast majority of CAAX proteins. Prenylation has been shown to be essential for the proper intracellular targeting and function of several CAAX proteins, but the physiologic importance of the endoprotease step has remained less certain. Here, we will review methods that have been used to define the physiologic importance of the endoproteolytic processing step of CAAX protein processing.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Animals
- Cardiomyopathy
- Dilated
- etiology
- Cell Proliferation
- Cell Transformation
- Neoplastic
- Cells
- Cultured
- Electrophoresis
- Polyacrylamide Gel
- Endopeptidases
- deficiency
- genetics
- physiology
- Fibroblasts
- metabolism
- Genes
- ras
- Hematopoiesis
- physiology
- Humans
- Liver
- physiology
- Methylation
- Mice
- Mice
- Knockout
- Mice
- Nude
- Mitogen-Activated Protein Kinase 1
- metabolism
- Mitogen-Activated Protein Kinase 3
- metabolism
- Myeloproliferative Disorders
- etiology
- Protein Processing
- Post-Translational
- Transfection
- ras Proteins
- isolation & purification
- metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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