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Demonstration of es...
Demonstration of estrogen receptor-beta immunoreactivity in human growth plate cartilage.
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- Nilsson, L O (författare)
- Karolinska Institutet
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- Boman, A (författare)
- Karolinska Institutet
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- Sävendahl, Lars (författare)
- Karolinska Institutet
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- Grigelioniene, G (författare)
- Karolinska Institutet
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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Ritz?n, E M (författare)
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Wroblewski, J (författare)
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- Ritzen, EM (författare)
- Karolinska Institutet
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(creator_code:org_t)
- The Endocrine Society, 1999
- 1999
- Engelska.
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 0021-972X. ; 84:1, s. 370-3
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Estrogens affect longitudinal bone growth through their action on endochondral bone formation. Two estrogen receptors are known, the classical estrogen receptor-alpha (ER alpha), newly demonstrated in human growth plate cartilage, and a recently cloned estrogen receptor-beta (ER beta). The present study aimed to localize a possible expression of ER beta protein in human growth plates. Tissue samples were obtained from tibial and femoral growth plates in four female pubertal patients undergoing epiphyseal surgery. Immunohistochemistry, using two different ER beta-specific antibodies, demonstrated positive staining for ER beta in hypertrophic epiphyseal chondrocytes from all patients. No staining was noted in resting or proliferative chondrocytes. These data suggest that in addition to ER alpha, human epiphyseal chondrocytes also express ER beta. The physiological role of ER beta in the regulation of longitudinal bone growth in humans remains to be elucidated.
Nyckelord
- Adolescent
- Antibody Specificity
- Child
- Estrogen Receptor beta
- Female
- Growth Plate
- chemistry
- Humans
- Immunohistochemistry
- Receptors
- Estrogen
- analysis
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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