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Expression of exon ...
Expression of exon 3-retaining and exon 3-excluding isoforms of the human growth hormone-receptor is regulated in an interindividual, rather than a tissue-specific, manner.
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- Wickelgren, Ruth, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Landin-Wilhelmsen, Kerstin, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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- Ohlsson, Claes, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för internmedicin,Institute of Internal Medicine, Dept of Medicine
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visa fler...
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- Carlsson, Lena M S, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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visa färre...
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(creator_code:org_t)
- 1995
- 1995
- Engelska.
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Ingår i: The Journal of clinical endocrinology and metabolism. - 0021-972X. ; 80:7, s. 2154-7
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- GH has multiple effects on growth and metabolism, and these functions are mediated through binding to specific cell surface receptors. The human GH receptor (GHR) exists in two known isoforms; in one form exon 3 is present (GHR3+), and in the other, exon 3 is absent (GHR3-). Recent reports have suggested that the expression of the two isoforms is tissue specific and/or developmentally regulated. We used a reverse transcription-polymerase chain reaction assay to study the expression pattern of the two isoforms in a variety of tissues from normal subjects and patients with acromegaly. In skeletal muscle from both normal subjects and patients with acromegaly, the GHR3+ transcript was expressed, either alone or together with the shorter (GHR3-) transcript. When multiple tissues from six subjects were tested, the expression of the two isoforms varied among subjects, whereas different tissues from the same subject showed the same expression pattern. These results indicate that the expression of the GHR isoforms is not tissue specific. Instead, the expression of the GHR isoforms appears to be specific for each individual, suggesting that it is under the control of factors that affect all tissues in the body.
Nyckelord
- Adipose Tissue
- metabolism
- Adolescent
- Adult
- Aged
- Aged
- 80 and over
- Base Sequence
- Bone and Bones
- metabolism
- Cartilage
- metabolism
- Child
- Child
- Preschool
- DNA Primers
- Exons
- Female
- Gene Expression Regulation
- Humans
- Infant
- Liver
- metabolism
- Male
- Middle Aged
- Molecular Sequence Data
- Muscle
- Skeletal
- metabolism
- Organ Specificity
- Polymerase Chain Reaction
- Receptors
- Somatotropin
- biosynthesis
- genetics
- Skin
- metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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