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Expression of prote...
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Inci, KamuranGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education
(författare)
Expression of protease-activated-receptor 2 (PAR-2) in human esophageal mucosa.
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-07-08
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Informa UK Limited,2009
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LIBRIS-ID:oai:gup.ub.gu.se/94504
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https://gup.ub.gu.se/publication/94504URI
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https://doi.org/10.1080/00365520902783683DOI
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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OBJECTIVE: The role of duodenal reflux in gastroesophageal reflux disease (GERD) containing bile salts and pancreatic enzymes (with special attention to trypsin) is still under discussion. Proteinase-activated receptors (PARs) are a novel family and PAR-2 is a unique member of this family because it is activated by trypsin. The aim of the present study was to examine the presence and the position of the PAR-2 receptor in human esophageal mucosa in different subgroups of GERD. MATERIAL AND METHODS: Distal biopsies taken from healthy controls, patients with erosive reflux disease (ERD), patients with specialized intestinal metaplasia (SIM) and adenocarcinoma were analyzed for the PAR-2 receptor with reverse-transcription polymerase chain reaction (RT-PCR), Western blotting and immunohistochemistry. RESULTS: Gene transcripts for the PAR-2 receptor were found in all groups, with increased levels in SIM patients compared to controls. However, this visual pattern was not seen for the protein expression of the PAR-2 receptor showing no apparent quantitative differences between the groups. Immunohistochemistry revealed distinct staining for the PAR-2 receptor in the luminal part of the esophageal epithelium. CONCLUSIONS: The localization of the PAR-2 receptor indicates that the receptor can be cleaved and activated by trypsin in duodenogastric esophageal refluxate. The data thus suggest that the trypsin-PAR-2 pathway may be involved in the pathogenesis of GERD.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Edebo, Anders,1968Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xedean
(författare)
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Olbe, LarsGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education
(författare)
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Casselbrant, Anna,1970Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xcassa
(författare)
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Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning
(creator_code:org_t)
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Ingår i:Scandinavian journal of gastroenterology: Informa UK Limited44:6, s. 664-711502-77080036-5521
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