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Modulation of low-f...
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Strandberg, Joakim,1978Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
(författare)
Modulation of low-frequency-induced synaptic depression in the developing CA3-CA1 hippocampal synapses by NMDA and metabotropic glutamate receptor activation.
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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American Physiological Society,2009
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LIBRIS-ID:oai:gup.ub.gu.se/99483
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https://gup.ub.gu.se/publication/99483URI
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https://doi.org/10.1152/jn.91210.2008DOI
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Ämneskategori:ref swepub-contenttype
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Brief test-pulse stimulation (0.2-0.05 Hz) of naïve (previously nonstimulated) developing hippocampal CA3-CA1 synapses leads to a substantial synaptic depression, explained by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) silencing. Using field recordings in hippocampal slices from P8 to P12 rats, we examined this depression of naïve synapses using more prolonged test-pulse stimulation as well as low-frequency (1 Hz) stimulation (LFS). We found that 900 stimuli produced depression during stimulation to approximately 40% of the naïve level independent of whether test-pulse stimulation or LFS was used. This result was also observed during combined blockade of N-methyl-d-aspartate/metabotropic glutamate receptors (NMDAR/mGluRs) although the depression was smaller (to approximately 55% of naïve level). Using separate blockade of either NMDARs or mGluRs, we found that this impairment of the depression resulted from the NMDAR, and not from the mGluR, blockade. In fact, during NMDAR blockade alone, depression was smaller even than that observed during combined blockade. We also found that mGluR blockade alone facilitated the LFS-induced depression. In conclusion, test-pulse stimulation produced as much depression as LFS when applied to naïve synapses even when allowing for NMDAR and mGluR activation. Our results seem in line with the notion that NMDARs and mGluRs may exert a bidirectional control on AMPA receptor recruitment to synapses.
Ämnesord och genrebeteckningar
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Animals
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Animals
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Newborn
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Biophysics
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Electric Stimulation
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methods
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Excitatory Amino Acid Antagonists
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pharmacology
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Excitatory Postsynaptic Potentials
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drug effects
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physiology
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Hippocampus
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cytology
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Long-Term Synaptic Depression
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drug effects
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physiology
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Neural Pathways
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physiology
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Rats
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Rats
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Wistar
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Receptors
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Metabotropic Glutamate
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antagonists & inhibitors
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physiology
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Receptors
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N-Methyl-D-Aspartate
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antagonists & inhibitors
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physiology
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Synapses
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drug effects
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physiology
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wasling, Pontus,1970Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xwaspo
(författare)
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Gustafsson, Bengt,1946Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xgbenk
(författare)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för fysiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of neurophysiology: American Physiological Society101:5, s. 2252-620022-30771522-1598
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