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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 16463naa a2202557 4500 | |
| 001 | oai:hhs.se:1155162180006056 | |
| 003 | SwePub | |
| 008 | 221125s2016 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:133635855 | |
| 024 | 7 | a https://research.hhs.se/esploro/outputs/journalArticle/Genetic-variants-associated-with-subjective-well-being/9910014807632060562 URI |
| 024 | 7 | a https://doi.org/10.1038/ng.35522 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1336358552 URI |
| 040 | a (SwePub)hhsd (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Frazier-Wood, Alexis C.u Baylor College of Medicine4 aut |
| 245 | 1 0 | a Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses |
| 264 | c 2016-04-18 | |
| 264 | 1 | b Nature Research (part of Springer Nature),c 2016 |
| 520 | a Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (vertical bar(p) over cap vertical bar approximate to 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Furlotte, Nicholas Au 23andMe4 aut |
| 700 | 1 | a Garfield, Victoriau University College London (GB)4 aut |
| 700 | 1 | a Geisel, Marie Henrikeu University Hospital of Essen4 aut |
| 700 | 1 | a Gonzalez, Juan Ru Institute for Global Health,Helmholtz Zentrum München-German Research Center for Environmental Health,University of Lausanne4 aut |
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| 700 | 1 | a Karlsson, Robertu Karolinska Institutet,Karolinska Institutet (SE)4 aut |
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| 700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet,Karolinska Institutet (SE)4 aut |
| 700 | 1 | a Plomin, Robertu King's College London (GB)4 aut |
| 700 | 1 | a Polasek, Ozrenu University of Split4 aut |
| 700 | 1 | a Power, Christineu South Australian Health and Medical Research Institute4 aut |
| 700 | 1 | a Rich, Stephen S.u University of Virginia (US)4 aut |
| 700 | 1 | a Ladwig, Karl-Heinzu Helmholtz Zentrum München-German Research Center for Environmental Health4 aut |
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| 700 | 1 | a van der Lee, Sven Ju Erasmus Medical Center,University of Minnesota Twin Cities (US)4 aut |
| 700 | 1 | a Lind, Penelope A.u QIMR Berghofer Medical Research Institute4 aut |
| 700 | 1 | a Liu, Tianu Max Planck Institute for Molecular Genetics4 aut |
| 700 | 1 | a Matteson, Lindsay K.u University of Minnesota Twin Cities (US)4 aut |
| 700 | 1 | a Mihailov, Evelinu Bristol University (GB)4 aut |
| 700 | 1 | a Miller, Mike B.u University of Minnesota Twin Cities (US),Institute for Research in Extramural Medicine (NL),VU University (NL)4 aut |
| 700 | 1 | a Minica, Camelia Cu Vrije Universiteit Amsterdam (NL)4 aut |
| 700 | 1 | a Nolte, IMu University of Groningen (NL),University of Minnesota Twin Cities (US),University of Oxford (GB)4 aut |
| 700 | 1 | a Mook-Kanamori, Dennisu Leiden University4 aut |
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| 700 | 1 | a Qian, Yongu National Institute on Aging (US),University of Queensland (AU)4 aut |
| 700 | 1 | a Raitakari, Olliu University of Turku4 aut |
| 700 | 1 | a Rawal, Rajeshu Helmholtz Zentrum München-German Research Center for Environmental Health,Leiden University,University of Michigan (US),National Institute on Aging (US),University of Edinburgh,Hunter Medical Research Institute4 aut |
| 700 | 1 | a Rosendaal, Frits Ru Leiden University4 aut |
| 700 | 1 | a Ruijter, Hester M denu UMC Utrecht4 aut |
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| 700 | 1 | a Schmidt, Reinholdu Medical University of Graz4 aut |
| 700 | 1 | a Realo, Anuu University of Tartu4 aut |
| 700 | 1 | a Rueedi, Ricou University of Lausanne4 aut |
| 700 | 1 | a Schmidt, Börgeu University Hospital of Essen4 aut |
| 700 | 1 | a Smith, Albert Vernonu Icelandic Heart Association (IS)4 aut |
| 700 | 1 | a Stergiakouli, Evieu Bristol University (GB)4 aut |
| 700 | 1 | a Tanaka, Toshikou National Institute on Aging (US),Helmholtz Zentrum München-German Research Center for Environmental Health4 aut |
| 700 | 1 | a Taylor, Kentu Los Angeles Biomedical Research Institute4 aut |
| 700 | 1 | a Thorleifsson, Gudmaru deCODE Genetics4 aut |
| 700 | 1 | a Schmidt, Helenau Medical University of Graz4 aut |
| 700 | 1 | a Svento, Rauliu Oulu Business School4 aut |
| 700 | 1 | a Alizadeh, Behrooz Zu University of Groningen (NL)4 aut |
| 700 | 1 | a Sørensen, Thorkild I Au Copenhagen University (DK)4 aut |
| 700 | 1 | a Spector, Tim Du King's College London (GB)4 aut |
| 700 | 1 | a Starr, John M.u University of Edinburgh4 aut |
| 700 | 1 | a Stefansson, Kariu deCODE Genetics4 aut |
| 700 | 1 | a Steptoe, Andrewu University College London (GB)4 aut |
| 700 | 1 | a Wedenoja, Juhou University of Helsinki (FI)4 aut |
| 700 | 1 | a Wellmann, Juergenu University of Münster4 aut |
| 700 | 1 | a Westra, Harm-Janu Brigham and Women's Hospital and Harvard Medical School4 aut |
| 700 | 1 | a Willems, Sara Mu Erasmus Medical Center,Erasmus University (NL)4 aut |
| 700 | 1 | a Zhao, Weiu University of Michigan (US)4 aut |
| 700 | 1 | a Amin, Najafu Erasmus Medical Center4 aut |
| 700 | 1 | a Bakshi, Andrewu University of Queensland (AU)4 aut |
| 700 | 1 | a Bergmann, Svenu University of Lausanne4 aut |
| 700 | 1 | a Terracciano, Antoniou National Institute on Aging (US)4 aut |
| 700 | 1 | a Thorsteinsdottir, Unnuru University of Iceland4 aut |
| 700 | 1 | a Thurik, A. Royu Erasmus School of Economics (NL)4 aut |
| 700 | 1 | a Timpson, Nicholas Ju Bristol University (GB)4 aut |
| 700 | 1 | a Tiemeier, Henningu Erasmus University (NL)4 aut |
| 700 | 1 | a Uitterlinden, André G.u Erasmus University (NL)4 aut |
| 700 | 1 | a Vollenweider, Peteru University of Lausanne4 aut |
| 700 | 1 | a Wagner, Gert Gu Berlin University of Technology4 aut |
| 700 | 1 | a Bjornsdottir, Gydau deCODE Genetics4 aut |
| 700 | 1 | a Boyle, Patricia A.u Rush University Medical Center4 aut |
| 700 | 1 | a Cherney, Samanthau RAND Corporation4 aut |
| 700 | 1 | a Davis, Oliver S. P.u Bristol University (GB)4 aut |
| 700 | 1 | a Ding, Junu National Institute on Aging (US)4 aut |
| 700 | 1 | a Direk, Neseu Erasmus Medical Center4 aut |
| 700 | 1 | a Eibich, Peteru Karolinska Institutet,University of Oxford (GB)4 aut |
| 700 | 1 | a Emeny, Rebecca Tu Helmholtz Zentrum München-German Research Center for Environmental Health4 aut |
| 700 | 1 | a Weir, David Ru University of Michigan (US)4 aut |
| 700 | 1 | a Fatemifar, Ghazalehu University College London (GB)4 aut |
| 700 | 1 | a Faul, Jessica D.u University of Michigan (US)4 aut |
| 700 | 1 | a Ferrucci, Luigiu National Institute on Aging (US)4 aut |
| 700 | 1 | a Forstner, Andreas J.u University of Bonn4 aut |
| 700 | 1 | a Gieger, Christianu Helmholtz Zentrum München-German Research Center for Environmental Health4 aut |
| 700 | 1 | a Gupta, Richau University of Helsinki (FI)4 aut |
| 700 | 1 | a Harris, Tamara B.u National Institute on Aging (US)4 aut |
| 700 | 1 | a Harris, Juliette Mu King's College London (GB)4 aut |
| 700 | 1 | a Yang, Jianu University of Queensland (AU)4 aut |
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| 700 | 1 | a Davey-Smith, Georgeu Bristol University (GB)4 aut |
| 700 | 1 | a Holliday, Elizabeth Gu Newcastle University4 aut |
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| 700 | 1 | a Laibson, Davidu Harvard University (US)4 aut |
| 700 | 1 | a Medland, Sara E.u Queensland Institute of Medical Research4 aut |
| 700 | 1 | a Meyer, Michelle Nu Clarkson University,VU University (NL)4 aut |
| 700 | 1 | a Pickrell, Joseph K.u New York Genome Center4 aut |
| 700 | 1 | a Krueger, Robert Fredericku University of Minnesota Twin Cities (US)4 aut |
| 700 | 1 | a Launer, Lenore J.u National Institute on Aging (US)4 aut |
| 700 | 1 | a Franke, Ludeu University of Groningen (NL)4 aut |
| 700 | 1 | a Li-Gao, Ruifangu Leiden University4 aut |
| 700 | 1 | a Liewald, David C.u University of Edinburgh,Center for Experimental Social Science4 aut |
| 700 | 1 | a Koini, Marisau Medical University of Graz4 aut |
| 700 | 1 | a Loukola, Anuu University of Helsinki (FI)4 aut |
| 700 | 1 | a Marques-Vidal, Pedrou University of Lausanne4 aut |
| 700 | 1 | a Montgomery, Grant Wu QIMR Berghofer Medical Research Institute4 aut |
| 700 | 1 | a Beauchamp, Jonathan Pu Harvard University (US)4 aut |
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| 700 | 1 | a Trzaskowski, Macieju University of Queensland (AU)4 aut |
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| 700 | 1 | a Yu, Leiu Rush University Medical Center4 aut |
| 700 | 1 | a Zabaneh, Delilahu King's College London (GB)4 aut |
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| 700 | 1 | a Gratten, Jacobu University of Queensland (AU)4 aut |
| 700 | 1 | a Lee, James J.u University of Minnesota Twin Cities (US)4 aut |
| 700 | 1 | a Liu, Jimmy Z.u New York Genome Center4 aut |
| 700 | 1 | a de Vlaming, Ronaldu Erasmus School of Economics (NL)4 aut |
| 700 | 1 | a Ahluwalia, Tarunveer Singhu Copenhagen University (DK)4 aut |
| 700 | 1 | a Buchwald, Jadwigau University of Helsinki (FI)4 aut |
| 700 | 1 | a Cavadino, Alanau Queen Mary University of London4 aut |
| 700 | 1 | a Kubzansky, Laura Du Harvard T.H. Chan School of Public Health4 aut |
| 700 | 1 | a Lehtimäki, Terhou University of Tampere (FI)4 aut |
| 700 | 1 | a Magnusson, Patrik K. E.u Karolinska Institutet (SE)4 aut |
| 700 | 1 | a Martin, N.G.u Queensland Institute of Medical Research4 aut |
| 700 | 1 | a McGue, Mattu University of Minnesota Twin Cities (US)4 aut |
| 700 | 1 | a Metspalu, Andresu University of Tartu4 aut |
| 700 | 1 | a Mills, Melindau University of Oxford (GB)4 aut |
| 700 | 1 | a Mutsert, Renée deu Leiden University4 aut |
| 710 | 2 | a Baylor College of Medicineb 23andMe4 org |
| 773 | 0 | t Nature Geneticsd : Nature Research (part of Springer Nature)g 48, s. 624-+q 48<624-+x 1061-4036x 1546-1718 |
| 856 | 4 | u https://europepmc.org/articles/pmc4884152?pdf=render |
| 856 | 4 8 | u https://research.hhs.se/esploro/outputs/journalArticle/Genetic-variants-associated-with-subjective-well-being/991001480763206056 |
| 856 | 4 8 | u https://doi.org/10.1038/ng.3552 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:133635855 |
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