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Therapeutic Effects...
Therapeutic Effects of IL-1RA against Acute Bacterial Infections, including Antibiotic-Resistant Strains
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- Ambite, Ines (författare)
- Lund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups
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- Tran, Thi Hien (författare)
- Lund University,Lunds universitet,Cancerinfektion,Forskargrupper vid Lunds universitet,Cancer Infection,Lund University Research Groups
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- Butler, Daniel S.C. (författare)
- Lund University,Lunds universitet,Cancerinfektion,Forskargrupper vid Lunds universitet,Cancer Infection,Lund University Research Groups
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- Cavalera, Michele (författare)
- Lund University,Lunds universitet,Cancerinfektion,Forskargrupper vid Lunds universitet,Cancer Infection,Lund University Research Groups
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- Wan, Murphy Lam Yim (författare)
- Lund University,Lunds universitet,Cancerinfektion,Forskargrupper vid Lunds universitet,Cancer Infection,Lund University Research Groups
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- Ahmadi, Shahram (författare)
- Lund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups
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- Svanborg, Catharina (författare)
- Lund University,Lunds universitet,Cancerinfektion,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cancer Infection,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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(creator_code:org_t)
- 2024
- 2024
- Engelska.
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Ingår i: Pathogens. - 2076-0817. ; 13:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Innate immunity is essential for the anti-microbial defense, but excessive immune activation may cause severe disease. In this study, immunotherapy was shown to prevent excessive innate immune activation and restore the anti-bacterial defense. E. coli-infected Asc−/− mice develop severe acute cystitis, defined by IL-1 hyper-activation, high bacterial counts, and extensive tissue pathology. Here, the interleukin-1 receptor antagonist (IL-1RA), which inhibits IL-1 hyper-activation in acute cystitis, was identified as a more potent inhibitor of inflammation and NK1R- and substance P-dependent pain than cefotaxime. Furthermore, IL-1RA treatment inhibited the excessive innate immune activation in the kidneys of infected Irf3−/− mice and restored tissue integrity. Unexpectedly, IL-1RA also accelerated bacterial clearance from infected bladders and kidneys, including antibiotic-resistant E. coli, where cefotaxime treatment was inefficient. The results suggest that by targeting the IL-1 response, control of the innate immune response to infection may be regained, with highly favorable treatment outcomes, including infections caused by antibiotic-resistant strains.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- acute cystitis
- acute pyelonephritis
- antibiotic resistance
- IL-1
- IL-1 receptor antagonist
- immunotherapy
- infection
- substance P
- urinary tract infection
- uropathogenic Escherichia coli
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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