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Bleeding phenotype ...
Bleeding phenotype of patients with moderate haemophilia A and B assessed by thromboelastometry and thrombin generation
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- Måseide, Ragnhild J. (författare)
- University of Oslo,Oslo university hospital
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- Berntorp, Erik (författare)
- Lund University,Lunds universitet,Klinisk koagulationsmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Coagulation, Malmö,Lund University Research Groups
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- Nummi, Vuokko (författare)
- Helsinki University Central Hospital,University of Helsinki
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- Lassila, Riitta (författare)
- Helsinki University Central Hospital
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- Tjønnfjord, Geir E. (författare)
- Oslo university hospital,University of Oslo
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- Holme, Pål A. (författare)
- University of Oslo,Oslo university hospital
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(creator_code:org_t)
- 2021-06-09
- 2021
- Engelska.
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Ingår i: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 27:5, s. 793-801
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Predicting the bleeding phenotype is crucial for the management of patients with moderate haemophilia. Global coagulation assays evaluate haemostasis more comprehensively than conventional methods. Aim: To explore global coagulation assays and the bleeding phenotype of patients with moderate haemophilia A (MHA) and B (MHB). Methods: The MoHem study is a cross-sectional, multicentre study covering Nordic patients with MHA and MHB. Thromboelastometry in whole blood and thrombin generation (TG) in platelet-poor plasma (1, 2.5 and 5 pM tissue factor (TF)) were compared with joint health (Haemophilia Joint Health Score (HJHS)) and treatment modality. Results: We report on 61 patients from Oslo and Helsinki: 24 MHA and 37 MHB. By TG (2.5 pM TF), patients who had been without replacement therapy during the previous 12 months depicted higher endogenous thrombin potential (P =.03). In contrast, those who had low ETP (< median) captured higher HJHS (P =.02). Patients who had undergone orthopaedic surgery generated least thrombin (P =.02). By thromboelastometry, those without the need of factor consumption had short clotting times, and quick times to maximum velocity (< median values) (P =.03). Factor VIII/factor IX activity (FVIII/FIX:C) did not align with the bleeding phenotype, but FIX:C ≤ 3 IU/dL was associated with lower peak thrombin (P =.03). Conclusion: TG differentiated patients with moderate haemophilia according to HJHS, annual factor consumption, and whether orthopaedic surgery had been performed. Thromboelastometry differentiated according to factor consumption only. Global coagulation assays may assist predicting the bleeding phenotype in moderate haemophilia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- bleeding phenotype
- joint score
- moderate haemophilia A
- moderate haemophilia B
- thrombin generation
- thromboelastometry
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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