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Evaluation of multi...
Evaluation of multiple transcriptomic gene risk signatures in male breast cancer
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- Bayani, Jane (författare)
- Ontario Institute for Cancer Research,University of Toronto
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- Poncet, Coralie (författare)
- European Organisation for Research and Treatment of Cancer
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- Crozier, Cheryl (författare)
- Ontario Institute for Cancer Research
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- Neven, Anouk (författare)
- European Organisation for Research and Treatment of Cancer
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- Piper, Tammy (författare)
- University of Edinburgh
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- Cunningham, Carrie (författare)
- University of Edinburgh
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- Sobol, Monika (författare)
- University of Edinburgh
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- Aebi, Stefan (författare)
- SAKK Coordinating Center
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- Benstead, Kim (författare)
- Cheltenham General Hospital
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- Bogler, Oliver (författare)
- University of Texas
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- Dal Lago, Lissandra (författare)
- Institut Jules Bordet
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Fraser, Judith (författare)
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- Hilbers, Florentine (författare)
- Breast International Group
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- Hedenfalk, Ingrid (författare)
- Lund University,Lunds universitet,Bröst- och ovarialcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/ovarialcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breast and Ovarian Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/ovarian cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Korde, Larissa (författare)
- University of Washington
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- Linderholm, Barbro (författare)
- Sahlgrenska University Hospital
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- Martens, John (författare)
- Erasmus University Medical Center
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- Middleton, Lavinia (författare)
- University of Texas
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- Murray, Melissa (författare)
- Memorial Sloan-Kettering Cancer Center
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Kelly, Catherine (författare)
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Nilsson, Cecilia (författare)
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Nowaczyk, Monika (författare)
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Peeters, Stephanie (författare)
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- Peric, Aleksandra (författare)
- European Organisation for Research and Treatment of Cancer
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- Porter, Peggy (författare)
- University of Washington
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- Schröder, Carolien (författare)
- University Medical Center Groningen
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- Rubio, Isabel T. (författare)
- Bellvitge University Hospital-IDIBELL
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- Ruddy, Kathryn J. (författare)
- Mayo Clinic Minnesota
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- van Asperen, Christi (författare)
- Leiden University Medical Centre
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Van Den Weyngaert, Danielle (författare)
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- van Deurzen, Carolien (författare)
- Erasmus University Medical Center
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- van Leeuwen-Stok, Elise (författare)
- Dutch Breast Cancer Research Group (BOOG)
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Vermeij, Joanna (författare)
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- Winer, Eric (författare)
- Dana-Farber Cancer Institute
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- Giordano, Sharon H. (författare)
- University of Texas
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Cardoso, Fatima (författare)
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- Bartlett, John M.S. (författare)
- University of Toronto,University of Edinburgh
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(creator_code:org_t)
- 2021-07-26
- 2021
- Engelska.
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Ingår i: npj Breast Cancer. - : Springer Science and Business Media LLC. - 2374-4677. ; 7:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Male breast cancer (BCa) is a rare disease accounting for less than 1% of all breast cancers and 1% of all cancers in males. The clinical management is largely extrapolated from female BCa. Several multigene assays are increasingly used to guide clinical treatment decisions in female BCa, however, there are limited data on the utility of these tests in male BCa. Here we present the gene expression results of 381 M0, ER+ve, HER2-ve male BCa patients enrolled in the Part 1 (retrospective analysis) of the International Male Breast Cancer Program. Using a custom NanoString™ panel comprised of the genes from the commercial risk tests Prosigna®, OncotypeDX®, and MammaPrint®, risk scores and intrinsic subtyping data were generated to recapitulate the commercial tests as described by us previously. We also examined the prognostic value of other risk scores such as the Genomic Grade Index (GGI), IHC4-mRNA and our prognostic 95-gene signature. In this sample set of male BCa, we demonstrated prognostic utility on univariate analysis. Across all signatures, patients whose samples were identified as low-risk experienced better outcomes than intermediate-risk, with those classed as high risk experiencing the poorest outcomes. As seen with female BCa, the concordance between tests was poor, with C-index values ranging from 40.3% to 78.2% and Kappa values ranging from 0.17 to 0.58. To our knowledge, this is the largest study of male breast cancers assayed to generate risk scores of the current commercial and academic risk tests demonstrating comparable clinical utility to female BCa.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Bayani, Jane
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Poncet, Coralie
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Crozier, Cheryl
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Neven, Anouk
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Piper, Tammy
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Cunningham, Carr ...
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visa fler...
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Sobol, Monika
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Aebi, Stefan
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Benstead, Kim
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Bogler, Oliver
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Dal Lago, Lissan ...
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Fraser, Judith
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Hilbers, Florent ...
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Hedenfalk, Ingri ...
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Korde, Larissa
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Linderholm, Barb ...
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Martens, John
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Middleton, Lavin ...
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Murray, Melissa
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Kelly, Catherine
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Nilsson, Cecilia
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Nowaczyk, Monika
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Peeters, Stephan ...
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Peric, Aleksandr ...
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Porter, Peggy
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Schröder, Caroli ...
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Rubio, Isabel T.
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Ruddy, Kathryn J ...
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van Asperen, Chr ...
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Van Den Weyngaer ...
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van Deurzen, Car ...
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van Leeuwen-Stok ...
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Vermeij, Joanna
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Winer, Eric
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Giordano, Sharon ...
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Cardoso, Fatima
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Bartlett, John M ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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npj Breast Cance ...
- Av lärosätet
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Lunds universitet