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Cell-type-specific ...
Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes
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- Zhang, Tongwu (författare)
- National Cancer Institute, USA
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- Choi, Jiyeon (författare)
- National Cancer Institute, USA
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- Kovacs, Michael A. (författare)
- National Cancer Institute, USA
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- Shi, Jianxin (författare)
- National Cancer Institute, USA
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- Xu, Mai (författare)
- National Cancer Institute, USA
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Consortium, Melanoma Meta Analysis (författare)
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- Goldstein, Alisa M. (författare)
- National Cancer Institute, USA
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- Trower, Adam J. (författare)
- University of Leeds
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- Bishop, D. Timothy (författare)
- University of Leeds
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- Iles, Mark M. (författare)
- University of Leeds
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- Duffy, David L. (författare)
- QIMR Berghofer Medical Research Institute
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- MacGregor, Stuart (författare)
- QIMR Berghofer Medical Research Institute
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- Amundadottir, Laufey T. (författare)
- National Cancer Institute, USA
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- Law, Matthew H. (författare)
- QIMR Berghofer Medical Research Institute
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- Loftus, Stacie K. (författare)
- National Human Genome Research Institute
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- Pavan, William J. (författare)
- National Human Genome Research Institute
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- Brown, Kevin M. (författare)
- National Cancer Institute, USA
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- Olsson, Håkan (creator_code:cre_t)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Melanoma Study Group,Lund University Research Groups
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(creator_code:org_t)
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- 2018-10-17
- 2018
- Engelska.
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Ingår i: Genome Research. - : Cold Spring Harbor Laboratory. - 1088-9051 .- 1549-5469. ; 28:11, s. 1621-1635
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://genome.cshlp....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Most expression quantitative trait locus (eQTL) studies to date have been performed in heterogeneous tissues as opposed to specific cell types. To better understand the cell-type-specific regulatory landscape of human melanocytes, which give rise to melanoma but account for <5% of typical human skin biopsies, we performed an eQTL analysis in primary melanocyte cultures from 106 newborn males. We identified 597,335 cis-eQTL SNPs prior to linkage disequilibrium (LD) pruning and 4997 eGenes (FDR < 0.05). Melanocyte eQTLs differed considerably from those identified in the 44 GTEx tissue types, including skin. Over a third of melanocyte eGenes, including key genes in melanin synthesis pathways, were unique to melanocytes compared to those of GTEx skin tissues or TCGA melanomas. The melanocyte data set also identified trans-eQTLs, including those connecting a pigmentation-associated functional SNP with four genes, likely through cis-regulation of IRF4. Melanocyte eQTLs are enriched in cis-regulatory signatures found in melanocytes as well as in melanoma-associated variants identified through genome-wide association studies. Melanocyte eQTLs also colocalized with melanoma GWAS variants in five known loci. Finally, a transcriptome-wide association study using melanocyte eQTLs uncovered four novel susceptibility loci, where imputed expression levels of five genes (ZFP90, HEBP1, MSC, CBWD1, and RP11-383H13.1) were associated with melanoma at genome-wide significant P-values. Our data highlight the utility of lineage-specific eQTL resources for annotating GWAS findings, and present a robust database for genomic research of melanoma risk and melanocyte biology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zhang, Tongwu
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Choi, Jiyeon
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Kovacs, Michael ...
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Shi, Jianxin
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Xu, Mai
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Consortium, Mela ...
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visa fler...
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Goldstein, Alisa ...
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Trower, Adam J.
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Bishop, D. Timot ...
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Iles, Mark M.
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Duffy, David L.
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MacGregor, Stuar ...
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Amundadottir, La ...
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Law, Matthew H.
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Loftus, Stacie K ...
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Pavan, William J ...
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Brown, Kevin M.
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Olsson, Håkan
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Genome Research
- Av lärosätet
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Lunds universitet