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Carrier detection i...
Carrier detection in hemophilia A : a cooperative international study. II. The efficacy of a universal discriminant
- Artikel/kapitelEngelska1986
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LIBRIS-ID:oai:lup.lub.lu.se:05fba024-738c-432f-9247-ee00cb4edc69
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https://lup.lub.lu.se/record/05fba024-738c-432f-9247-ee00cb4edc69URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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Factor VIII (F.VIII) and von Willebrand factor (VWF):Ag data collected by eight laboratories on a total of 336 obligatory carriers of hemophilia A and 137 normal women were used to answer several questions concerning the construction of linear discriminants for carrier detection. It was found: that a "universal" linear discriminant can be constructed which is suitable for use in all laboratories and is nearly as effective as laboratory-specific discriminants; that inclusion of age and ABO blood type data improved the efficacy of these discriminants; that substitution of alternative assays for F.VIII and VWF:Ag did not generally improve the efficacy of the discriminants over that obtained using the bioassay for F.VIII:C and Laurell's immunoassay for VWF:Ag; that linear discriminants were far more effective than discriminants based on the F.VIII:C/VWF:Ag ratio. A step-wise procedure is given which any laboratory may follow in using the universal discriminant for carrier detection.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Mannucci, P M
(författare)
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Briët, E
(författare)
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Ljung, RLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk hematologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Paediatric Haematology Research Unit,Lund University Research Groups(Swepub:lu)pedi-rlj
(författare)
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Kasper, C K
(författare)
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Essien, E M
(författare)
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Chediak, J
(författare)
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Rizza, C R
(författare)
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Graham, J B
(författare)
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Pediatrik, LundSektion V
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Blood67:6, s. 7-15600006-4971
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