Sökning: onr:"swepub:oai:lup.lub.lu.se:06bf9518-2e4e-4bef-b1e4-0e9bb5c7443d" >
Rapid test for lung...
-
Verder, HenrikHolbaek University Hospital, Denmark
(författare)
Rapid test for lung maturity, based on spectroscopy of gastric aspirate, predicted respiratory distress syndrome with high sensitivity
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:06bf9518-2e4e-4bef-b1e4-0e9bb5c7443d
-
https://lup.lub.lu.se/record/06bf9518-2e4e-4bef-b1e4-0e9bb5c7443dURI
-
https://doi.org/10.1111/apa.13683DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-136627URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Funding Agencies|European Unions Horizon research and innovation programme
-
Aim: Respiratory distress syndrome (RDS) is a major cause of mortality and morbidity in premature infants. By the time symptoms appear, it may already be too late to prevent a severe course, with bronchopulmonary dysplasia or mortality. We aimed to develop a rapid test of lung maturity for targeting surfactant supplementation. Methods: Concentrations of the most surface-active lung phospholipid dipalmitoylphosphatidylcholine and sphingomyelin in gastric aspirates from premature infants were measured by mass spectrometry and expressed as the lecithin/sphingomyelin ratio (L/S). The same aspirates were analysed with mid-infrared spectroscopy. Subsequently, L/S was measured in gastric aspirates and oropharyngeal secretions from another group of premature infants using spectroscopy and the results were compared with RDS development. The 10-minute analysis required 10 μL of aspirate. Results: An L/S algorithm was developed based on 89 aspirates. Subsequently, gastric aspirates were sampled in 136 infants of 24-31 weeks of gestation and 61 (45%) developed RDS. The cut-off value of L/S was 2.2, sensitivity was 92%, and specificity was 73%. In 59 cases, the oropharyngeal secretions had less valid L/S than gastric aspirate results. Conclusion: Our rapid test for lung maturity, based on spectroscopy of gastric aspirate, predicted RDS with high sensitivity.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Heiring, ChristianUniversity of Copenhagen, Denmark
(författare)
-
Clark, HowardUniversity of Southampton, England
(författare)
-
Sweet, DavidRoyal Jubilee Maternity Hospital,Royal Matern Hospital, North Ireland
(författare)
-
Jessen, Torben E.Holbaek University Hospital, Denmark
(författare)
-
Ebbesen, FinnAalborg University, Denmark
(författare)
-
Björklund, Lars J.Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital, Sweden; Lund University, Sweden(Swepub:lu)pedi-lbj
(författare)
-
Andreasson, BengtSkåne University Hospital, Lund, Sweden
(författare)
-
Bender, LarsAalborg University, Denmark
(författare)
-
Bertelsen, AkselHolbaek University Hospital, Holbaek, Denmark
(författare)
-
Dahl, MarianneOdense University Hospital,University of Southen, Denmark
(författare)
-
Eschen, ChristianHolbaek University Hospital, Holbaek, Denmark
(författare)
-
Fenger-Grøn, JesperUniversity of Soouthern, Denmark
(författare)
-
Hoffmann, Stine F.University of Copenhagen, Denmark
(författare)
-
Höskuldsson, AgnarHolbaek University Hospital, Denmark
(författare)
-
Bruusgaard-Mouritsen, MariaHolbaek University Hospital, Denmark
(författare)
-
Lundberg, FredrikLinköpings universitet,Linköping University,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten(Swepub:liu)frelu52
(författare)
-
Postle, Anthony D.Southampton General Hospital,University of Southampton, England
(författare)
-
Schousboe, PeterHolbaek University Hospital, Denmark
(författare)
-
Schmidt, PeterUniversity of Copenhagen, Denmark
(författare)
-
Stanchev, HristoNaestved University Hospital, Denmark
(författare)
-
Sørensen, LarsHolbaek University Hospital, Denmark
(författare)
-
Holbaek University Hospital, DenmarkUniversity of Copenhagen, Denmark
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Acta Paediatrica, International Journal of Paediatrics: Wiley106:3, s. 430-4370803-52531651-2227
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Verder, Henrik
-
Heiring, Christi ...
-
Clark, Howard
-
Sweet, David
-
Jessen, Torben E ...
-
Ebbesen, Finn
-
visa fler...
-
Björklund, Lars ...
-
Andreasson, Beng ...
-
Bender, Lars
-
Bertelsen, Aksel
-
Dahl, Marianne
-
Eschen, Christia ...
-
Fenger-Grøn, Jes ...
-
Hoffmann, Stine ...
-
Höskuldsson, Agn ...
-
Bruusgaard-Mouri ...
-
Lundberg, Fredri ...
-
Postle, Anthony ...
-
Schousboe, Peter
-
Schmidt, Peter
-
Stanchev, Hristo
-
Sørensen, Lars
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Pediatrik
- Artiklar i publikationen
-
Acta Paediatrica ...
- Av lärosätet
-
Lunds universitet
-
Linköpings universitet