onr:"swepub:oai:lup.lub.lu.se:07151614-f0be-4520-bcee-4ef0ad039afa"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03562naa a2200385 4500 | |
| 001 | oai:lup.lub.lu.se:07151614-f0be-4520-bcee-4ef0ad039afa | |
| 003 | SwePub | |
| 008 | 160401s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/21802082 URI |
| 024 | 7 | a https://doi.org/10.2337/dc10-22012 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Abdul-Ghani, Muhammad A.4 aut |
| 245 | 1 0 | a Two-Step Approach for the Prediction of Future Type 2 Diabetes Risk |
| 264 | c 2011-08-19 | |
| 264 | 1 | b American Diabetes Association,c 2011 |
| 520 | a OBJECTIVE-To develop a model for the prediction of type 2 diabetes mellitus (T2DM) risk on the basis of a multivariate logistic model and 1-h plasma glucose concentration (1-h PG). RESEARCH DESIGN AND METHODS-The model was developed in a cohort of 1,562 non-diabetic subjects from the San Antonio Heart Study (SAHS) and validated in 2,395 nondiabetic subjects in the Botnia Study. A risk score on the basis of anthropometric parameters, plasma glucose and lipid profile, and blood pressure was computed for each subject. Subjects with a risk score above a certain cut point were considered to represent high-risk individuals, and their 1-h PG concentration during the oral glucose tolerance test was used to further refine their future T2DM risk. RESULTS-We used the San Antonio Diabetes Prediction Model (SADPM) to generate the initial risk score. A risk-score value of 0.065 was found to be an optimal cut point for initial screening and selection of high-risk individuals. A 1-h PG concentration >140 mg/dL in high-risk individuals (whose risk score was >0.065) was the optimal cut point for identification of subjects at increased risk. The two cut points had 77.8, 77.4, and 44.8% (for the SAHS) and 75.8, 71.6, and 11.9% (for the Botnia Study) sensitivity, specificity, and positive predictive value, respectively, in the SAHS and Botnia Study. CONCLUSIONS-A two-step model, based on the combination of the SADPM and 1-h PG, is a useful tool for the identification of high-risk Mexican-American and Caucasian individuals. Diabetes Care 34:2108-2112, 2011 | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 700 | 1 | a Abdul-Ghani, Tamam4 aut |
| 700 | 1 | a Stern, Michael P.4 aut |
| 700 | 1 | a Karavic, Jasmina4 aut |
| 700 | 1 | a Tuomi, Tiinamaijau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)ti8736tu |
| 700 | 1 | a Bo, Insoma4 aut |
| 700 | 1 | a DeFronzo, Ralph A.4 aut |
| 700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
| 710 | 2 | a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Diabetes Cared : American Diabetes Associationg 34:9, s. 2108-2112q 34:9<2108-2112x 1935-5548x 0149-5992 |
| 856 | 4 | u http://dx.doi.org/10.2337/dc10-2201y FULLTEXT |
| 856 | 4 | u https://europepmc.org/articles/pmc3161295?pdf=render |
| 856 | 4 8 | u https://lup.lub.lu.se/record/2180208 |
| 856 | 4 8 | u https://doi.org/10.2337/dc10-2201 |
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