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Ferryl hemoglobin a...
Ferryl hemoglobin and heme induce Α1‐microglobulin in hemorrhaged atherosclerotic lesions with inhibitory function against hemoglobin and lipid oxidation
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- Pethő, Dávid (författare)
- University of Debrecen
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- Gáll, Tamás (författare)
- University of Debrecen
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- Hendrik, Zoltán (författare)
- University of Debrecen
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- Nagy, Annamária (författare)
- University of Debrecen
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- Beke, Lívia (författare)
- University of Debrecen
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- Gergely, Attila Péter (författare)
- University of Debrecen
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- Méhes, Gábor (författare)
- University of Debrecen
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- Tóth, Csaba (författare)
- University of Debrecen
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- Gram, Magnus (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Åkerström, Bo (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Antioxidationsmedicin,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Antioxidation medicine,Lund University Research Groups
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- Balla, György (författare)
- University of Debrecen
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- Balla, József (författare)
- University of Debrecen
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(creator_code:org_t)
- 2021-06-22
- 2021
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 22:13
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Infiltration of red blood cells into atheromatous plaques and oxidation of hemoglobin (Hb) and lipoproteins are implicated in the pathogenesis of atherosclerosis. α1‐microglobulin (A1M) is a radical‐scavenging and heme‐binding protein. In this work, we examined the origin and role of A1M in human atherosclerotic lesions. Using immunohistochemistry, we observed a significant A1M immunoreactivity in atheromas and hemorrhaged plaques of carotid arteries in smooth muscle cells (SMCs) and macrophages. The most prominent expression was detected in macrophages of organized hemorrhage. To reveal a possible inducer of A1M expression in ruptured lesions, we exposed aortic endothelial cells (ECs), SMCs and macrophages to heme, Oxy‐ and FerrylHb. Both heme and FerrylHb, but not OxyHb, upregulated A1M mRNA expression in all cell types. Importantly, only FerrylHb induced A1M protein secretion in aortic ECs, SMCs and macrophages. To assess the possible function of A1M in ruptured lesions, we analyzed Hb oxidation and heme‐catalyzed lipid peroxidation in the presence of A1M. We showed that recombinant A1M markedly inhibited Hb oxidation and heme‐driven oxidative modification of low‐density lipoproteins as well plaque lipids derived from atheromas. These results demonstrate the presence of A1M in atherosclerotic plaques and suggest its induction by heme and FerrylHb in the resident cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Atherosclerosis
- Ferryl hemoglobin
- Heme
- Hemoglobin oxidation
- Hemorrhage
- Oxidized lipoprotein
- α1‐microglobulin
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Pethő, Dávid
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Gáll, Tamás
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Hendrik, Zoltán
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Nagy, Annamária
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Beke, Lívia
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Gergely, Attila ...
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visa fler...
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Méhes, Gábor
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Tóth, Csaba
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Gram, Magnus
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Åkerström, Bo
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Balla, György
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Balla, József
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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International Jo ...
- Av lärosätet
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Lunds universitet