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A combined cell and...
A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells
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- Moriarty, Niamh (författare)
- University of Melbourne
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- Gantner, Carlos W. (författare)
- University of Melbourne
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- Hunt, Cameron P.J. (författare)
- University of Melbourne
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- Ermine, Charlotte M. (författare)
- University of Melbourne
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- Frausin, Stefano (författare)
- University of Melbourne
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- Viventi, Serena (författare)
- University of Melbourne
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- Ovchinnikov, Dmitry A. (författare)
- University of Melbourne
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- Kirik, Deniz (författare)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups,University of Sydney
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- Parish, Clare L. (författare)
- University of Melbourne
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- Thompson, Lachlan H. (författare)
- University of Melbourne
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska.
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Ingår i: Cell Stem Cell. - : Elsevier BV. - 1934-5909. ; 29:3, s. 5-448
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Midbrain dopamine (mDA) neurons can be replaced in patients with Parkinson's disease (PD) in order to provide long-term improvement in motor functions. The limited capacity for long-distance axonal growth in the adult brain means that cells are transplanted ectopically, into the striatal target. As a consequence, several mDA pathways are not re-instated, which may underlie the incomplete restoration of motor function in patients. Here, we show that viral delivery of GDNF to the striatum, in conjunction with homotopic transplantation of human pluripotent stem-cell-derived mDA neurons, recapitulates brain-wide mDA target innervation. The grafts provided re-instatement of striatal dopamine levels and correction of motor function and also connectivity with additional mDA target nuclei not well innervated by ectopic grafts. These results demonstrate the remarkable capacity for achieving functional and anatomically precise reconstruction of long-distance circuitry in the adult brain by matching appropriate growth-factor signaling to grafting of specific cell types.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- axon growth
- cell therapy
- GDNF
- neural transplantation
- neurotrophic
- Parkinson's disease
- PITX3
- regeneration
- retrograde tracing
- substantia nigra
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Moriarty, Niamh
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Gantner, Carlos ...
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Hunt, Cameron P. ...
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Ermine, Charlott ...
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Frausin, Stefano
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Viventi, Serena
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visa fler...
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Ovchinnikov, Dmi ...
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Kirik, Deniz
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Parish, Clare L.
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Thompson, Lachla ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Cell Stem Cell
- Av lärosätet
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Lunds universitet