Superficial CD34-Positive Fibroblastic Tumor : A Clinicopathologic, Immunohistochemical, and Molecular Study of 59 Cases

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Fältnamn	Indikatorer	Metadata
000		04216naa a2200397 4500
001		oai:lup.lub.lu.se:0bd3a177-3505-409f-9d55-ff5ca41db970
003		SwePub
008		230102s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/0bd3a177-3505-409f-9d55-ff5ca41db9702 URI
024	7	a https://doi.org/10.1097/PAS.00000000000019272 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Anderson, William J.u Brigham and Women's Hospital / Harvard Medical School4 aut
245	1 0	a Superficial CD34-Positive Fibroblastic Tumor : A Clinicopathologic, Immunohistochemical, and Molecular Study of 59 Cases
264	1	c 2022
300		a 11 s.
520		a Superficial CD34-positive fibroblastic tumor (SCD34FT) is a rare soft tissue neoplasm that shows overlapping features with PRDM10-rearranged soft tissue tumor (PRDM10-STT). This study characterizes the clinicopathologic, immunohistochemical, and molecular features of SCD34FT in a series of 59 cases. Fluorescence in situ hybridization to assess for PRDM10 rearrangement was performed in 12 tumors. Immunohistochemistry for CADM3 and WT1 was performed; CADM3 was also assessed in histologic mimics. Our cohort of 33 male and 26 female had a median age of 42 (range: 14 to 85) years. Tumors were most commonly located in the lower limb (73%), upper limb (8%), back (7%), and supraclavicular region (3%). The median tumor size was 3.0 cm (range: 1.0 to 9.0 cm). Clinical follow-up in 32 patients (median duration: 26 mo) revealed 2 local recurrences (6%). One patient developed regional lymph node metastases which were completely excised. Microscopically, SCD34FT comprised spindled and pleomorphic cells with glassy cytoplasm and occasional granular cell change. Fluorescence in situ hybridization confirmed PRDM10 rearrangement in 3/8 cases (38%). SCD34FT frequently expressed CADM3 (95%) and WT1 (75%). CADM3 was less diffusely positive in pleomorphic hyalinizing angiectatic tumor (40%), pleomorphic liposarcoma (20%), and undifferentiated pleomorphic sarcoma (10%). We corroborate that SCD34FT is indolent but may rarely metastasize to lymph nodes without adverse outcomes. CADM3 and WT1 may be useful in the distinction from histologic mimics. Since cases of SCD34FT with and without demonstrable PRDM10 rearrangement were clinicopathologically indistinguishable, our study further supports that SCD34FT and PRDM10-STT likely constitute a single entity.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653		a CADM3
653		a pleomorphic
653		a PRDM10
653		a sarcoma
653		a soft tissue
700	1	a Mertens, Fredriku Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetiska avvikelser i mjukdelstumörer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,The genetics of soft tissue tumors,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Regional Laboratories Region Skåne4 aut0 (Swepub:lu)kgen-fme
700	1	a Mariño-Enríquez, Adriánu Brigham and Women's Hospital / Harvard Medical School4 aut
700	1	a Hornick, Jason L.u Brigham and Women's Hospital / Harvard Medical School4 aut
700	1	a Fletcher, Christopher D.M.u Brigham and Women's Hospital / Harvard Medical School4 aut
710	2	a Brigham and Women's Hospital / Harvard Medical Schoolb Avdelningen för klinisk genetik4 org
773	0	t American Journal of Surgical Pathologyg 46:10, s. 1329-1339q 46:10<1329-1339x 0147-5185
856	4	u http://dx.doi.org/10.1097/PAS.0000000000001927y FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/0bd3a177-3505-409f-9d55-ff5ca41db970
856	4 8	u https://doi.org/10.1097/PAS.0000000000001927

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