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Sökning: onr:"swepub:oai:lup.lub.lu.se:0c545649-8190-425b-a760-b19bf59007f9" > Mapping the cord bl...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005560naa a2200505 4500
001oai:lup.lub.lu.se:0c545649-8190-425b-a760-b19bf59007f9
003SwePub
008220117s2022 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/0c545649-8190-425b-a760-b19bf59007f92 URI
0247 a https://doi.org/10.1210/clinem/dgac0102 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Hatem, Gadu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)ga5503ha
2451 0a Mapping the cord blood transcriptome of pregnancies affected by early maternal anemia to identify signatures of fetal programming
264 c 2022-01-11
264 1b The Endocrine Society,c 2022
520 a OBJECTIVE: Anemia during early pregnancy (EP) is common in developing countries and is associated with adverse health consequences for both mother and children. Offspring of women with EP anemia often have low birth-weight, the latter being a risk factor for cardiometabolic diseases including type 2 diabetes (T2D) later in life. Mechanisms underlying developmental programming of adult cardiometabolic disease include epigenetic and transcriptional alterations potentially detectable in umbilical cord blood (UCB) at time of birth.METHODS: We leveraged global transcriptome- and accompanying epigenome-wide changes in 48 UCB from newborns of EP-anemic Tanzanian mothers and 50 controls to identify differentially expressed genes (DEG) in UCB exposed to maternal EP-anemia. DEGs were assessed for association with neonatal anthropometry and cord insulin levels. These genes were further studied in expression data from human fetal pancreas and adult islets to understand their role in beta-cell development and/or function.RESULTS: The expression of 137 genes was altered in UCB of newborns exposed to maternal EP anemia. These putative signatures of fetal programming which included the birth-weight locus LCORL, were potentially mediated by epigenetic changes in 27 genes and associated with neonatal anthropometry. Among the DEGs were P2RX7, PIK3C2B, and NUMBL which potentially influence beta-cell development. Insulin levels were lower in EP anemia exposed UCB, supporting the notion of developmental programming of pancreatic beta-cell dysfunction and subsequently increased risk of T2D in offspring of EP anemic mothers.CONCLUSIONS: Our data provide proof-of-concept on distinct transcriptional and epigenetic changes detectable in UCB from newborns exposed to maternal EP anemia.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Hjort, Lineu Copenhagen University Hospital4 aut0 (Swepub:lu)li1517hj
7001 a Asplund, Olofu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)med-oap
7001 a Minja, Daniel T Ru National Institute for Medical Research Tanga4 aut
7001 a Msemo, Omari Abdulu National Institute for Medical Research Tanga4 aut
7001 a Møller, Sofie Lykkeu University of Copenhagen4 aut
7001 a Lavstsen, Thomasu University of Copenhagen4 aut
7001 a Groth-Grunnet, Louiseu University of Copenhagen4 aut
7001 a Lusingu, John P Au National Institute for Medical Research Tanga4 aut
7001 a Hansson, Olau Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)medk-oha
7001 a Christensen, Dirk Lundu University of Copenhagen4 aut
7001 a Vaag, Allan Au Steno Diabetes Center Copenhagen4 aut0 (Swepub:lu)med-ava
7001 a Artner, Isabellau Lund University,Lunds universitet,Endokrin Celldifferentiering,Forskargrupper vid Lunds universitet,Endocrine Cell Differentiation and Function,Lund University Research Groups4 aut0 (Swepub:lu)med-iba
7001 a Theander, Thoru University of Copenhagen4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)endo-lgr
7001 a Schmiegelow, Christentzeu University of Copenhagen4 aut
7001 a Bygbjerg, Ib Christianu University of Copenhagen4 aut
7001 a Prasad, Rashmi Bu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups4 aut0 (Swepub:lu)med-rpa
7102 a Translationell muskelforskningb Forskargrupper vid Lunds universitet4 org
7730 t The Journal of clinical endocrinology and metabolismd : The Endocrine Societyg 107:5, s. 1303-1316q 107:5<1303-1316x 1945-7197x 0021-972X
8564 u http://dx.doi.org/10.1210/clinem/dgac010x freey FULLTEXT
8564 u https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgac010/42376460/dgac010.pdf
8564 8u https://lup.lub.lu.se/record/0c545649-8190-425b-a760-b19bf59007f9
8564 8u https://doi.org/10.1210/clinem/dgac010

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