Sökning: onr:"swepub:oai:lup.lub.lu.se:0eae8cb9-97e8-4c6c-8e71-0464a32b7d2c" >
C-erbB2, p27 and G1...
C-erbB2, p27 and G1/S aberrations in human primary breast cancer
-
Loden, M (författare)
-
Perris, F (författare)
-
Nielsen, NH (författare)
-
visa fler...
-
Emdin, SO (författare)
-
- Landberg, Göran (författare)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups
-
visa färre...
-
(creator_code:org_t)
- 2003
- 2003
- Engelska.
-
Ingår i: Anticancer research. - 1791-7530. ; 23:3A, s. 2053-2061
- Relaterad länk:
-
https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- Background: C-erbB2 is overexpressed in approximately one-fourth of human breast cancers. In spite of numerous reports suggesting a connection of c-erbB2 overexpression with cell cycle regulation through p27, D cyclins and c-myc. the relationship between c-erbB2 and proliferation through de-regulation of the pRb pathway in primaty breast cancer has not been fully clarified. Materials and Methods: For this purpose we compared the expression of c-erbB2 in a total of 10.5 primary breast tumours with a variety of cell cycle proteins and clinical parameters. Results: GerbB2 was strongly con-elated with down-regulation of p27 and overexpression of c-erbB2 was', as expected, associated with poor survival. However, there was no correlation with proliferation. There was, nevertheless, an association between c-erbB2 and proliferation in certain subtypes of breast cancer, as in oestrogen-receptor-positive e tumours, tumours with high cyclin D1 and in tumours with an overall linear pRb pathway, i.e. tumours with a preserved linearity between cyclin D1, pRb phosphorylation and proliferation. Conclusion: Our results suggest that c-erbB2 may have alternative functions in different subtypes of breast cancer, and further stress that c-erbB2, in addition to promoting proliferation, also functions through other mechanisms in breast cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- proliferation
- pRb pathway
- cyclins
- p27
- breast cancer
- c-erbB2
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas