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Supplemental Associ...
Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure
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- Yu, Bing (författare)
- University of Texas
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- Roberts, Mary B. (författare)
- Brown University
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- Raffield, Laura M. (författare)
- University of North Carolina
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- Zekavat, Seyedeh Maryam (författare)
- Yale University,Broad Institute
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- Nguyen, Ngoc Quynh H. (författare)
- University of Texas
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- Biggs, Mary L. (författare)
- University of Washington,University of North Carolina
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- Brown, Michael R. (författare)
- University of Texas
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- Griffin, Gabriel (författare)
- Broad Institute
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- Desai, Pinkal (författare)
- Weill Cornell Medical College
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- Correa, Adolfo (författare)
- University of Mississippi Medical Center
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- Morrison, Alanna C. (författare)
- University of Texas
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- Shah, Amil M. (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Niroula, Abhishek (författare)
- Lund University,Lunds universitet,Hematogenomics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Broad Institute,Dana-Farber Cancer Institute
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- Uddin, Md Mesbah (författare)
- Broad Institute
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- Honigberg, Michael C. (författare)
- Harvard Medical School,Massachusetts General Hospital,Broad Institute
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- Ebert, Benjamin L. (författare)
- Howard Hughes Medical Institute,Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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- Psaty, Bruce M. (författare)
- Washington University School of Medicine
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- Whitsel, Eric A. (författare)
- University of North Carolina
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- Manson, Jo Ann E. (författare)
- Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School
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- Kooperberg, Charles (författare)
- Fred Hutchinson Cancer Research Center
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- Bick, Alexander G. (författare)
- Vanderbilt University
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- Ballantyne, Christie M. (författare)
- Baylor College of Medicine
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- Reiner, Alex P. (författare)
- Fred Hutchinson Cancer Research Center
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- Natarajan, Pradeep (författare)
- Harvard Medical School,Broad Institute,Massachusetts General Hospital
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- Eaton, Charles B. (författare)
- Brown University
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(creator_code:org_t)
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- Elsevier BV, 2021
- 2021
- Engelska 11 s.
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Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 78:1, s. 42-52
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Age-related clonal hematopoiesis of indeterminate potential (CHIP), defined as clonally expanded leukemogenic sequence variations (particularly in DNMT3A, TET2, ASXL1, and JAK2) in asymptomatic individuals, is associated with cardiovascular events, including recurrent heart failure (HF). Objectives: This study sought to evaluate whether CHIP is associated with incident HF. Methods: CHIP status was obtained from whole exome or genome sequencing of blood DNA in participants without prevalent HF or hematological malignancy from 5 cohorts. Cox proportional hazards models were performed within each cohort, adjusting for demographic and clinical risk factors, followed by fixed-effect meta-analyses. Large CHIP clones (defined as variant allele frequency >10%), HF with or without baseline coronary heart disease, and left ventricular ejection fraction were evaluated in secondary analyses. Results: Of 56,597 individuals (59% women, mean age 58 years at baseline), 3,406 (6%) had CHIP, and 4,694 developed HF (8.3%) over up to 20 years of follow-up. CHIP was prospectively associated with a 25% increased risk of HF in meta-analysis (hazard ratio: 1.25; 95% confidence interval: 1.13-1.38) with consistent associations across cohorts. ASXL1, TET2, and JAK2 sequence variations were each associated with an increased risk of HF, whereas DNMT3A sequence variations were not associated with HF. Secondary analyses suggested large CHIP was associated with a greater risk of HF (hazard ratio: 1.29; 95% confidence interval: 1.15-1.44), and the associations for CHIP on HF with and without prior coronary heart disease were homogenous. ASXL1 sequence variations were associated with reduced left ventricular ejection fraction. Conclusions: CHIP, particularly sequence variations in ASXL1, TET2, and JAK2, represents a new risk factor for HF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- clonal hematopoiesis of indeterminate potential
- heart failure
- risk factor
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- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Yu, Bing
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Roberts, Mary B.
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Raffield, Laura ...
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Zekavat, Seyedeh ...
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Nguyen, Ngoc Quy ...
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Biggs, Mary L.
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visa fler...
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Brown, Michael R ...
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Griffin, Gabriel
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Desai, Pinkal
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Correa, Adolfo
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Morrison, Alanna ...
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Shah, Amil M.
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Niroula, Abhishe ...
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Uddin, Md Mesbah
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Honigberg, Micha ...
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Ebert, Benjamin ...
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Psaty, Bruce M.
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Whitsel, Eric A.
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Manson, Jo Ann E ...
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Kooperberg, Char ...
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Bick, Alexander ...
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Ballantyne, Chri ...
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Reiner, Alex P.
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Natarajan, Prade ...
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Eaton, Charles B ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Journal of the A ...
- Av lärosätet
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Lunds universitet