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Sökning: onr:"swepub:oai:lup.lub.lu.se:0fb60118-e55e-415e-8d89-3475b8618c02" > The association of ...

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FältnamnIndikatorerMetadata
00005085naa a2200817 4500
001oai:lup.lub.lu.se:0fb60118-e55e-415e-8d89-3475b8618c02
003SwePub
008160401s2007 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:115087682
0247 a https://lup.lub.lu.se/record/6632612 URI
0247 a https://doi.org/10.1371/journal.pgen.00300612 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1150876822 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Lyon, Helen N.4 aut
2451 0a The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
264 c 2007-04-27
264 1b Public Library of Science (PLoS),c 2007
520 a A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the minor allele was first observed in data from a genome-wide association scan of 86,604 SNPs in 923 related individuals from the Framingham Heart Study offspring cohort. The association was reproduced in four additional cohorts, but was not seen in a fifth cohort. To further assess the general reproducibility of this association, we genotyped rs7566605 in nine large cohorts from eight populations across multiple ethnicities (total n = 16,969). We tested this variant for association with BMI in each sample under a recessive model using family-based, population-based, and case-control designs. We observed a significant (p < 0.05) association in five cohorts but saw no association in three other cohorts. There was variability in the strength of association evidence across examination cycles in longitudinal data from unrelated individuals in the Framingham Heart Study Offspring cohort. A combined analysis revealed significant independent validation of this association in both unrelated (p = 0.046) and family-based (p = 0.004) samples. The estimated risk conferred by this allele is small, and could easily be masked by small sample size, population stratification, or other confounders. These validation studies suggest that the original association is less likely to be spurious, but the failure to observe an association in every data set suggests that the effect of SNP rs7566605 on BMI may be heterogeneous across population samples.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Emilsson, Valur4 aut
7001 a Hinney, Anke4 aut
7001 a Heid, Iris M.4 aut
7001 a Lasky-Su, Jessica4 aut
7001 a Zhu, Xiaofeng4 aut
7001 a Thorleifsson, Gudmar4 aut
7001 a Gunnarsdottir, Steinunn4 aut
7001 a Walters, G. Bragi4 aut
7001 a Thorsteinsdottir, Unnur4 aut
7001 a Kong, Augustine4 aut
7001 a Gulcher, Jeffrey4 aut
7001 a Nguyen, Thuy Trang4 aut
7001 a Scherag, Andre4 aut
7001 a Pfeufer, Arne4 aut
7001 a Meitinger, Thomas4 aut
7001 a Broenner, Guenter4 aut
7001 a Rief, Winfried4 aut
7001 a Soto-Quiros, Manuel E.4 aut
7001 a Avila, Lydiana4 aut
7001 a Klanderman, Barbara4 aut
7001 a Raby, Benjamin A.4 aut
7001 a Silverman, Edwin K.4 aut
7001 a Weiss, Scott T.4 aut
7001 a Laird, Nan4 aut
7001 a Ding, Xiao4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
7001 a Tuomi, Tiinamaija4 aut
7001 a Isomaa, Bo4 aut
7001 a Bengtsson, Kristina4 aut
7001 a Butler, Johannah L.4 aut
7001 a Cooper, Richard S.4 aut
7001 a Fox, Caroline S.4 aut
7001 a O'Donnell, Christopher J.4 aut
7001 a Vollmert, Caren4 aut
7001 a Celedon, Juan C.4 aut
7001 a Wichmann, H. Erich4 aut
7001 a Hebebrand, Johannes4 aut
7001 a Stefansson, Kari4 aut
7001 a Lange, Christophu Karolinska Institutet4 aut
7001 a Hirschhorn, Joel N.4 aut
7102 a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
7730 t PLoS Geneticsd : Public Library of Science (PLoS)g 3:4q 3:4x 1553-7404
8564 u http://dx.doi.org/10.1371/journal.pgen.0030061x freey FULLTEXT
8564 u https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.0030061&type=printable
8564 8u https://lup.lub.lu.se/record/663261
8564 8u https://doi.org/10.1371/journal.pgen.0030061
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:115087682

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