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Context-Dependent D...
Context-Dependent Development of Lymphoid Stroma from Adult CD34(+) Adventitial Progenitors.
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- Sitnik, Katarzyna M (författare)
- Tech Univ Denmark, Natl Vet Inst, Sect Immunol & Vaccinol, Bulowsvej 27, DK-1870 Frederiksberg C, Denmark.
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- Wendland, Kerstin (författare)
- Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups,Lund Univ, Immunol Sect, BMC D14, S-22184 Lund, Sweden.
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- Weishaupt, Holger (författare)
- Uppsala universitet,Neuroonkologi
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- Uronen-Hansson, Heli (författare)
- Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups,Lund Univ, Immunol Sect, BMC D14, S-22184 Lund, Sweden.
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- White, Andrea J (författare)
- Univ Birmingham, Inst Biomed Res, Ctr Immune Regulat, MRC, Birmingham B15 2TT, W Midlands, England.
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- Anderson, Graham (författare)
- Univ Birmingham, Inst Biomed Res, Ctr Immune Regulat, MRC, Birmingham B15 2TT, W Midlands, England.
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- Kotarsky, Knut (författare)
- Lund University,Lunds universitet,Slemhinnans immunologi,Forskargrupper vid Lunds universitet,Mucosal Immunology,Lund University Research Groups,Lund Univ, Immunol Sect, BMC D14, S-22184 Lund, Sweden.
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- Agace, William W (författare)
- Tech Univ Denmark, Natl Vet Inst, Sect Immunol & Vaccinol, Bulowsvej 27, DK-1870 Frederiksberg C, Denmark.;Lund Univ, Immunol Sect, BMC D14, S-22184 Lund, Sweden.
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Tech Univ Denmark, Natl Vet Inst, Sect Immunol & Vaccinol, Bulowsvej 27, DK-1870 Frederiksberg C, Denmark Slemhinnans immunologi (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 14:10, s. 2375-2388
- Relaterad länk:
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http://www.ncbi.nlm....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Despite the key role of primary and secondary lymphoid organ stroma in immunity, our understanding of the heterogeneity and ontogeny of these cells remains limited. Here, we identify a functionally distinct subset of BP3(-)PDPN(+)PDGFRβ(+)/α(+)CD34(+) stromal adventitial cells in both lymph nodes (LNs) and thymus that is located within the vascular niche surrounding PDPN(-)PDGFRβ(+)/α(-)Esam-1(+)ITGA7(+) pericytes. CD34(+) adventitial cells developed in late embryonic thymus and in postnatal LNs and in the thymus originated, along with pericytes, from a common anlage-seeding progenitor population. Using lymphoid organ re-aggregate grafts, we demonstrate that adult CD34(+) adventitial cells are capable of differentiating into multiple lymphoid stroma-like subsets including pericyte-, FRC-, MRC-, and FDC-like cells, the development of which was lymphoid environment-dependent. These findings extend the current understanding of lymphoid mesenchymal cell heterogeneity and highlight a role of the CD34(+) adventitia as a potential ubiquitous source of lymphoid stromal precursors in postnatal tissues.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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