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HIV-1 Transmission ...
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Nduva, George M.Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,Kenya Medical Research Institute (KEMRI)
(författare)
HIV-1 Transmission Patterns Within and Between Risk Groups in Coastal Kenya
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-04-21
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Springer Science and Business Media LLC,2020
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:0fdc9fb5-907d-4e10-93c5-c324bbfe98c5
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https://lup.lub.lu.se/record/0fdc9fb5-907d-4e10-93c5-c324bbfe98c5URI
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https://doi.org/10.1038/s41598-020-63731-zDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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HIV-1 transmission patterns within and between populations at different risk of HIV-1 acquisition in Kenya are not well understood. We investigated HIV-1 transmission networks in men who have sex with men (MSM), injecting drug users (IDU), female sex workers (FSW) and heterosexuals (HET) in coastal Kenya. We used maximum-likelihood and Bayesian phylogenetics to analyse new (N = 163) and previously published (N = 495) HIV-1 polymerase sequences collected during 2005–2019. Of the 658 sequences, 131 (20%) were from MSM, 58 (9%) IDU, 109 (17%) FSW, and 360 (55%) HET. Overall, 206 (31%) sequences formed 61 clusters. Most clusters (85%) consisted of sequences from the same risk group, suggesting frequent within-group transmission. The remaining clusters were mixed between HET/MSM (7%), HET/FSW (5%), and MSM/FSW (3%) sequences. One large IDU-exclusive cluster was found, indicating an independent sub-epidemic among this group. Phylodynamic analysis of this cluster revealed a steady increase in HIV-1 infections among IDU since the estimated origin of the cluster in 1987. Our results suggest mixing between high-risk groups and heterosexual populations and could be relevant for the development of targeted HIV-1 prevention programmes in coastal Kenya.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hassan, Amin S.Lund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,Kenya Medical Research Institute (KEMRI)(Swepub:lu)am3643ha
(författare)
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Nazziwa, JamirahLund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups(Swepub:lu)ja7181na
(författare)
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Graham, Susan M.University of Washington,Kenya Medical Research Institute (KEMRI)
(författare)
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Esbjörnsson, JoakimLund University,Lunds universitet,Systemvirologi,Forskargrupper vid Lunds universitet,Systems Virology,Lund University Research Groups,University of Oxford(Swepub:lu)med-jes
(författare)
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Sanders, Eduard J.Kenya Medical Research Institute (KEMRI),University of Oxford
(författare)
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SystemvirologiForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scientific Reports: Springer Science and Business Media LLC10:12045-2322
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