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Contractile propert...
Contractile properties of lymphatics from the human lower leg
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- Sjöberg, Trygve (författare)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Steen, Stig (författare)
- Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- 1991
- 1991
- Engelska.
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Ingår i: Lymphology. - 0024-7766. ; 24:1, s. 16-21
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- Lower leg lymphatics, taken from seven volunteers, were investigated in vitro. Isometric contractions were induced by noradrenaline, 5-hydroxytryptamine (5-HT), prostaglandin F2 alpha (PGF2 alpha), and the thromboxane A2 (TXA2)-mimetic U-44069. Noradrenaline induced phasic contractions in 6 of 7 segments. The amplitude of the contractions were up to 100% of a previous K+ (124mM)-induced contraction and the frequency at 10(-6)M of noradrenaline was 5-13 min-1. These contractions were unaffected by propranolol (10(-6)M), but they were abolished by phentolamine (10(-6)M). Noradrenaline had an Emax (tonic contraction) of 7% of the K+ (124mM) contraction (n = 7) and the pEC50-value was 6.9 (n = 3). The corresponding values for 5-HT were 21% (n = 5) and 6.4 (n = 3). PGF2 alpha elicited contractions in all segments investigated (Emax = 87%, pEC50 = 5.8, n = 5). U-44069 had high contractile capacity and potency in all investigated segments (Emax = 137%, pEC50 = 8.9, n = 7). Phasic contractions were elicited also by 5-HT, PGF2 alpha and U-44069. Compared to earlier studies of human peripheral lymphatics, these results show that there are regional differences in susceptibility to these vasoactive agents.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
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