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Noninvasive Assessm...
Noninvasive Assessment of Atrioventricular Nodal Function: Effect of Rate-Control Drugs during Atrial Fibrillation
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Corino, Valentina D. A. (författare)
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- Sandberg, Frida (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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Mainardi, Luca T. (författare)
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- Platonov, Pyotr (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Sörnmo, Leif (författare)
- Lund University,Lunds universitet,Avdelningen för Biomedicinsk teknik,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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(creator_code:org_t)
- 2014-12-26
- 2015
- Engelska.
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Ingår i: Annals of Noninvasive Electrocardiology. - : Wiley. - 1082-720X. ; 20:6, s. 534-541
- Relaterad länk:
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http://dx.doi.org/10...
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https://europepmc.or...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: During atrial fibrillation (AF), conventional electrophysiological techniques for assessment of refractory period or conduction velocity of the atrioventricular (AV) node cannot be used. We aimed at evaluating changes in AV nodal properties during administration of tecadenoson and esmolol using a novel ECG-based method. Methods: Fourteen patients (age 58 +/- 8 years, 10 men) with AF were randomly assigned to either 75 or 300 mu g intravenous tecadenoson. After tecadenoson wash-out, patients received esmolol continuously (100 mu g/kg per min for 10 mins, then 50 mu g/kg per min for 50 mins). Atrial fibrillatory rate (AFR) and heart rate (HR) were assessed in 15-min segments. Using the novel method, we assessed the absolute refractory periods of the slow and fast pathways (aRPs and aRPf) of the AV node to produce an estimate of the functional refractory period. Results: During esmolol infusion, AFR and HR were significantly decreased and the absolute refractory period was significantly prolonged in both pathways (aRPs: 387 +/- 73 vs 409 +/- 62 ms, P < 0.05; aRPf: 490 +/- 80 vs 529 +/- 58 ms, P < 0.05). During both tecadenoson doses, HR decreased significantly and AFR was unchanged. Both aRPs and aRPf were prolonged for a 75 mu g dose (aRPs: 322 +/- 97 vs 476 +/- 75 ms, P < 0.05; aRPf: 456 +/- 102 vs 512 +/- 55 ms, P < 0.05) whereas a trend toward prolongation was observed for a 300 mu g dose. Conclusions: The estimated parameters reflect expected changes in AV nodal properties, i.e., slower conduction through the AV node for tecadenoson and prolongation of the AV node refractory period for esmolol. Thus, the proposed approach may be used to assess drug effects on the AV node in AF patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- atrioventricular node
- atrial fibrillation
- functional refractory
- period
- tecadenoson
- esmolol
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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