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Genetic contributio...
Genetic contribution to the divergence in type 1 diabetes risk between children from the general population and children from affected families
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- Hippich, Markus (författare)
- Helmholtz Zentrum München
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- Beyerlein, Andreas (författare)
- Helmholtz Zentrum München,Klinikum rechts der Isar
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- Hagopian, William A. (författare)
- Pacific Northwest Research Institute
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- Krischer, Jeffrey P. (författare)
- University of South Florida
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- Vehik, Kendra (författare)
- University of South Florida
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- Knoop, Jan (författare)
- Helmholtz Zentrum München
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- Winker, Christiane (författare)
- Helmholtz Zentrum München
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- Toppari, Jorma (författare)
- Turku University Hospital,University of Turku
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Rewers, Marian J. (författare)
- University of Colorado
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- Steck, Andrea K. (författare)
- University of Colorado
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- She, Jin Xiong (författare)
- Medical College of Georgia
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- Akolkar, Beena (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Robertson, Catherine C. (författare)
- University of Virginia
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- Onengut-Gumuscu, Suna (författare)
- University of Virginia
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- Rich, Stephen S. (författare)
- University of Virginia
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- Bonifacio, Ezio (författare)
- Helmholtz Zentrum München,Dresden University of Technology
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- Ziegler, Anette G. (författare)
- Klinikum rechts der Isar,Helmholtz Zentrum München
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(creator_code:org_t)
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- 2019-01-17
- 2019
- Engelska 11 s.
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 68:4, s. 847-857
- Relaterad länk:
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http://dx.doi.org/10...
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visa fler...
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https://diabetes.dia...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general population (GP children). We analyzed children with high-risk HLA genotypes (n = 4,573) in the longitudinal TEDDY birth cohort to determine how much of the divergent risk is attributable to genetic enrichment in affected families. Enrichment for susceptible genotypes of multiple type 1 diabetes–associated genes and a novel risk gene, BTNL2, was identified in FDR children compared with GP children. After correction for genetic enrichment, the risks in the FDR and GP children converged but were not identical for multiple islet autoantibodies (hazard ratio [HR] 2.26 [95% CI 1.6–3.02]) and for diabetes (HR 2.92 [95% CI 2.05–4.16]). Convergence varied depending upon the degree of genetic susceptibility. Risks were similar in the highest genetic susceptibility group for multiple islet autoantibodies (14.3% vs .12.7%) and diabetes (4.8% vs. 4.1%) and were up to 5.8-fold divergent for children in the lowest genetic susceptibility group, decreasing incrementally in GP children but not in FDR children. These findings suggest that additional factors enriched within affected families preferentially increase the risk of autoimmunity and type 1 diabetes in lower genetic susceptibility strata.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- ref (ämneskategori)
Hitta via bibliotek
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Diabetes
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Till lärosätets databas
- Av författaren/redakt...
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Hippich, Markus
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Beyerlein, Andre ...
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Hagopian, Willia ...
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Krischer, Jeffre ...
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Vehik, Kendra
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Knoop, Jan
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visa fler...
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Winker, Christia ...
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Toppari, Jorma
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Lernmark, Åke
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Rewers, Marian J ...
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Steck, Andrea K.
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She, Jin Xiong
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Akolkar, Beena
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Robertson, Cathe ...
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Onengut-Gumuscu, ...
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Rich, Stephen S.
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Bonifacio, Ezio
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Ziegler, Anette ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes
- Av lärosätet
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Lunds universitet