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Resistin is elevate...
Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro
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Lee, J. H. (författare)
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Ort, T. (författare)
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Ma, K. (författare)
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Picha, K. (författare)
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Carton, J. (författare)
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Marsters, P. A. (författare)
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- Lohmander, Stefan (författare)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Baribaud, F. (författare)
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Song, X. -Y. R. (författare)
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Blake, S. (författare)
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(creator_code:org_t)
- 2009
- 2009
- Engelska.
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Ingår i: Osteoarthritis and Cartilage. - 1063-4584. ; 17:5, s. 613-620
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objective: Resistin is a secreted factor that is elevated in rheumatoid arthritis (RA) and believed to drive joint inflammation in vivo. This study was undertaken to determine if resistin is present in the joint following joint injury and to elucidate the role of resistin in cartilage degradation. Methods: The level of resistin was measured in paired synovial fluid (SF) and serum samples from patients following joint injury (anterior cruciate ligament, ACL or meniscus tear). Localization of resistin was visualized by immunohistochemistry of synovial tissue and cartilage from healthy and CA donors. Mouse and human cartilage cultures were used to assess the effect of resistin on cartilage metabolism. Results: In trauma patients, resistin levels declined with increasing time post injury. The resistin levels were highest in samples collected up to 1 week following traumatic injury (SF: 2980 pg/ml, serum: 7901 pg/ml) and lowest in samples collected 6-26 years post injury (SF: 686 pg/ml, serum: 5682 pg/ml). Resistin was shown to be expressed in macrophage-like cells in both healthy and OA synovial tissue. Treatment of mouse cartilage cultures with recombinant resistin led to a dose dependent loss of proteoglycan and induction of inflammatory cytokine and PGE(2) production. Recombinant resistin inhibited proteoglycan synthesis in human cartilage explants. Conclusion: Resistin is elevated both systemically and locally in the weeks immediately following joint injury and has a direct effect on cartilage matrix turnover and cytokine production. Resistin may play a role in the early stages of trauma-induced CA and may represent a new therapeutic target to slow joint destruction in CA. (C) 2008 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Cytokine
- Injury
- Osteoarthritis
- Resistin
- Cartilage
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lee, J. H.
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Ort, T.
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Ma, K.
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Picha, K.
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Carton, J.
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Marsters, P. A.
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visa fler...
-
Lohmander, Stefa ...
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Baribaud, F.
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Song, X. -Y. R.
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Blake, S.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
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Osteoarthritis a ...
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Lunds universitet